Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.357 extracted from

  • Penning, T.; Burczynski, M.; Jez, J.; Hung, C.; Lin, H.; Ma, H.; Moore, M.; Palackal, N.; Ratnam, K.
    Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones (2000), Biochem. J., 351, 67-77.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00144
-
5alpha-androstane-3,17-dione isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
0.0034
-
5alpha-dihydrotestosterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
0.00504
-
androsterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
0.0105
-
3alpha-androstanediol isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NAD(P)H + H+ Homo sapiens
-
estrone + NAD(P)+
-
?
20alpha-hydroxyprogesterone + NAD(P)H + H+ Homo sapiens
-
progesterone + NAD(P)+
-
?
3alpha-androstanediol + NAD(P)+ Homo sapiens
-
5alpha-dihydrotestosterone + NAD(P)H + H+
-
r
5alpha-androstane-3,17-dione + NAD(P)H + H+ Homo sapiens
-
androsterone + NAD(P)+
-
?
5alpha-dihydrotestosterone + NAD(P)H + H+ Homo sapiens
-
3alpha-androstanediol + NAD(P)+
-
r
androsterone + NAD(P)+ Homo sapiens
-
5alpha-androstane-3,17-dione + NAD(P)H + H+
-
?
estrone + NAD(P)H + H+ Homo sapiens
-
17beta-estradiol + NAD(P)+
-
?
progesterone + NAD(P)H + H+ Homo sapiens
-
20alpha-hydroxyprogesterone + NAD(P)+
-
?
testosterone + NAD(P)H + H+ Homo sapiens
-
DELTA4-androstene-3,17-dione + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P17516
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NAD(P)H + H+
-
Homo sapiens estrone + NAD(P)+
-
?
20alpha-hydroxyprogesterone + NAD(P)H + H+
-
Homo sapiens progesterone + NAD(P)+
-
?
3alpha-androstanediol + NAD(P)+
-
Homo sapiens 5alpha-dihydrotestosterone + NAD(P)H + H+
-
r
5alpha-androstane-3,17-dione + NAD(P)H + H+
-
Homo sapiens androsterone + NAD(P)+
-
?
5alpha-dihydrotestosterone + NAD(P)H + H+
-
Homo sapiens 3alpha-androstanediol + NAD(P)+
-
r
androsterone + NAD(P)+
-
Homo sapiens 5alpha-androstane-3,17-dione + NAD(P)H + H+
-
?
estrone + NAD(P)H + H+
-
Homo sapiens 17beta-estradiol + NAD(P)+
-
?
progesterone + NAD(P)H + H+
-
Homo sapiens 20alpha-hydroxyprogesterone + NAD(P)+
-
?
testosterone + NAD(P)H + H+
-
Homo sapiens DELTA4-androstene-3,17-dione + NAD(P)+
-
?

Synonyms

Synonyms Comment Organism
3alpha-hydroxysteroid dehydrogenase
-
Homo sapiens
AKR1C4 isoform Homo sapiens
chlordecone reductase
-
Homo sapiens
dihydrodiol dehydrogenase 4
-
Homo sapiens
type 1 3alpha-HSD
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.023
-
androsterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
0.03
-
5alpha-androstane-3,17-dione isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
0.033
-
5alpha-dihydrotestosterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
0.035
-
3alpha-androstanediol isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADP+
-
Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.33
-
3alpha-androstanediol isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
4.6
-
androsterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
9.77
-
5alpha-dihydrotestosterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
20.72
-
5alpha-androstane-3,17-dione isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens