KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00144 | - |
5alpha-androstane-3,17-dione | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens | |
0.0034 | - |
5alpha-dihydrotestosterone | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens | |
0.00504 | - |
androsterone | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens | |
0.0105 | - |
3alpha-androstanediol | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol + NAD(P)H + H+ | Homo sapiens | - |
estrone + NAD(P)+ | - |
? | |
20alpha-hydroxyprogesterone + NAD(P)H + H+ | Homo sapiens | - |
progesterone + NAD(P)+ | - |
? | |
3alpha-androstanediol + NAD(P)+ | Homo sapiens | - |
5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
r | |
5alpha-androstane-3,17-dione + NAD(P)H + H+ | Homo sapiens | - |
androsterone + NAD(P)+ | - |
? | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | Homo sapiens | - |
3alpha-androstanediol + NAD(P)+ | - |
r | |
androsterone + NAD(P)+ | Homo sapiens | - |
5alpha-androstane-3,17-dione + NAD(P)H + H+ | - |
? | |
estrone + NAD(P)H + H+ | Homo sapiens | - |
17beta-estradiol + NAD(P)+ | - |
? | |
progesterone + NAD(P)H + H+ | Homo sapiens | - |
20alpha-hydroxyprogesterone + NAD(P)+ | - |
? | |
testosterone + NAD(P)H + H+ | Homo sapiens | - |
DELTA4-androstene-3,17-dione + NAD(P)+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17516 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol + NAD(P)H + H+ | - |
Homo sapiens | estrone + NAD(P)+ | - |
? | |
20alpha-hydroxyprogesterone + NAD(P)H + H+ | - |
Homo sapiens | progesterone + NAD(P)+ | - |
? | |
3alpha-androstanediol + NAD(P)+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
r | |
5alpha-androstane-3,17-dione + NAD(P)H + H+ | - |
Homo sapiens | androsterone + NAD(P)+ | - |
? | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
Homo sapiens | 3alpha-androstanediol + NAD(P)+ | - |
r | |
androsterone + NAD(P)+ | - |
Homo sapiens | 5alpha-androstane-3,17-dione + NAD(P)H + H+ | - |
? | |
estrone + NAD(P)H + H+ | - |
Homo sapiens | 17beta-estradiol + NAD(P)+ | - |
? | |
progesterone + NAD(P)H + H+ | - |
Homo sapiens | 20alpha-hydroxyprogesterone + NAD(P)+ | - |
? | |
testosterone + NAD(P)H + H+ | - |
Homo sapiens | DELTA4-androstene-3,17-dione + NAD(P)+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
AKR1C4 | isoform | Homo sapiens |
chlordecone reductase | - |
Homo sapiens |
dihydrodiol dehydrogenase 4 | - |
Homo sapiens |
type 1 3alpha-HSD | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.023 | - |
androsterone | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens | |
0.03 | - |
5alpha-androstane-3,17-dione | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens | |
0.033 | - |
5alpha-dihydrotestosterone | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens | |
0.035 | - |
3alpha-androstanediol | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADP+ | - |
Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.33 | - |
3alpha-androstanediol | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens | |
4.6 | - |
androsterone | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens | |
9.77 | - |
5alpha-dihydrotestosterone | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens | |
20.72 | - |
5alpha-androstane-3,17-dione | isoform AKR1C4, at pH 7.4 and 25°C | Homo sapiens |