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Literature summary for 1.1.1.363 extracted from

  • Crans, D.C., Schelble, S.M.
    Vanadate dimer and tetramer both inhibit glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides (1990), Biochemistry, 29, 6698-6706.
    View publication on PubMed
Search for more literature for 1.1.1.363

Inhibitors

Inhibitors Comment Organism Structure
vanadate inhibition by vanadate dimer and tetramer. The inhibition by vanadate is competitive with respect to NAD+ or NADP+ and noncompetitive (a mixed type) with respect to glucose 6-phosphate when NAD+ or NADP+ are cofactors. The vanadate dimer is the major inhibiting species with respect to NADP+. The vanadate tetramer is the major inhibiting species with respect to glucose 6-phosphate and with respect to NAD+. No inhibition by monomeric vanadate Leuconostoc mesenteroides

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
 NADP+ 25°C, pH 7.1 Leuconostoc mesenteroides
0.073
-
 D-glucose 6-phosphate 25°C, pH 7.1, cosubstrate: NADP+ Leuconostoc mesenteroides
0.21
-
 D-glucose 6-phosphate 25°C, pH 7.1, cosubstrate: NAD+ Leuconostoc mesenteroides
0.35
-
 NAD+ 25°C, pH 7.1 Leuconostoc mesenteroides

Organism

Organism UniProt Comment Textmining
Leuconostoc mesenteroides
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NAD+
-
 Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADH + H+
-
 ?
D-glucose 6-phosphate + NADP+
-
 Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 vanadate inhibition constants with respect to D-glucose 6-phosphate, NAD+ or NADP+ Leuconostoc mesenteroides