Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NADP+ | Mus musculus | - |
pyruvate + CO2 + NADPH | - |
? | |
(S)-malate + NADP+ | Mus musculus | - |
pyruvate + CO2 + NADPH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | P06801 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
adipose tissue | - |
Mus musculus | - |
preadipocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NADP+ | - |
Mus musculus | pyruvate + CO2 + NADPH | - |
? | |
(S)-malate + NADP+ | - |
Mus musculus | pyruvate + CO2 + NADPH | - |
r |
Synonyms | Comment | Organism |
---|---|---|
malic enzyme | - |
Mus musculus |
ME1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Mus musculus | |
NADPH | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | during adipocyte differentiation, there is coordinate upregulation of ATP citrate lyase and cytosolic malic enzyme (ME1), which together with cytosolic malate dehydrogenase and at the expense of 1 ATP molecule, can convert citrate and NADH into acetyl-CoA, NADPH and pyruvate | Mus musculus |
additional information | tracing carbon flux through malic enzyme, overview | Mus musculus |
physiological function | significance of malic enzyme in fat synthesis. Malic enzyme is the main NADPH source in normoxic 3T3-L1 adipocytes, with total NADPH production more than double that from the oxidative pentose phosphate pathway | Mus musculus |