Literature summary for 1.1.1.41 extracted from

Yamada, S.; Kotake, Y.; Demizu, Y.; Kurihara, M.; Sekino, Y.; Kanda, Y.
NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells (2014), Sci. Rep., 4, 5952.

Search for more literature for 1.1.1.41

Cloned(Commentary)

Cloned (Comment)	Organism
gene IDH3A, real-time PCR expression analysis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	NAD-IDHalpha knockdown by shRNA	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
tributyltin	TBT, active in NT2/D1 carcinoma cells, overview. At nanomoler concentrations, tributyltin actions are mediated by genomic pathways via peroxisome proliferator-activated receptor gamma/retinoid X receptor, PPAR/RXR. Binding and in silico docking simulation analysis, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
isocitrate + NAD+	Homo sapiens	-	2-oxoglutarate + CO2 + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50213	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	-	Homo sapiens	-
NT2/D1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
isocitrate + NAD+	-	Homo sapiens	2-oxoglutarate + CO2 + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
hNAD-IDHalpha	-	Homo sapiens
IDH3A	-	Homo sapiens
IDH3alpha	-	Homo sapiens
NAD-dependent isocitrate dehydrogenase	-	Homo sapiens
NAD-IDH	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	specific for	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	NAD-IDH is a key enzyme in the tricarboxylic acid cycle	Homo sapiens
additional information	homology modeling and docking studies of the human NAD-IDHalpha, overview	Homo sapiens

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Release 2023.1 (January 2023)