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Literature summary for 1.1.1.42 extracted from

  • Leyland, M.L.; Kelly, D.J.
    Purification and characterization of a monomeric isocitrate dehydrogenase with dual coenzyme specificity from the photosynthetic bacterium Rhodomicrobium vannielii (1991), Eur. J. Biochem., 202, 85-93.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
 NADP+
-
 Rhodomicrobium vannielii
0.77
-
 NAD+
-
 Rhodomicrobium vannielii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000 80000 PAGE Rhodomicrobium vannielii
80000
-
 1 * 80000, SDS-PAGE Rhodomicrobium vannielii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Rhodomicrobium vannielii
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rhodomicrobium vannielii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rhodomicrobium vannielii

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
18.5
-
 NAD+-linked reaction Rhodomicrobium vannielii
23
-
 NADP+-linked reaction Rhodomicrobium vannielii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
 Rhodomicrobium vannielii 2-oxoglutarate + CO2 + NADH + H+
-
 r
isocitrate + NADP+
-
 Rhodomicrobium vannielii 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 80000, SDS-PAGE Rhodomicrobium vannielii

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rhodomicrobium vannielii
NADP+
-
 Rhodomicrobium vannielii