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Literature summary for 1.1.1.42 extracted from
- Versatile architecture of a bacterial aconitase B and its catalytic performance in the sequential reaction coupled with isocitrate dehydrogenase (2008), Biochim. Biophys. Acta, 1784, 1847-1856.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46200 | - |
2 * 46200, estimated from amino acid sequence | Escherichia coli |
| 85000 | - |
Guinier analysis | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P08200 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| His-tagged enzyme is purified by TALON resin column chromatography, ICDH fused maltose-binding protein is purified by amylose resin chromatography | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isocitrate + NADP+ | - |
Escherichia coli | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? |  |
| additional information | does not use citrate as substrate | Escherichia coli | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 46200, estimated from amino acid sequence | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ICDH | - |
Escherichia coli |
| isocitrate dehydrogenase | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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