Protein Variants | Comment | Organism |
---|---|---|
additional information | Idh2 gene deletion, generation of Idh2-/- mice, phenotype,overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | ischemia-reperfusion reduces IDH2 expression and activity in both Idh2+/+ and Idh2-/- kidneys | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NADP+ | Mus musculus | - |
2-oxoglutarate + CO2 + NADPH + H+ | - |
r | |
isocitrate + NADP+ | Mus musculus C57BL/6 | - |
2-oxoglutarate + CO2 + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P54071 | - |
- |
Mus musculus C57BL/6 | P54071 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
renal proximal tubule cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NADP+ | - |
Mus musculus | 2-oxoglutarate + CO2 + NADPH + H+ | - |
r | |
isocitrate + NADP+ | - |
Mus musculus C57BL/6 | 2-oxoglutarate + CO2 + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
IDH2 | - |
Mus musculus |
NADP+-dependent isocitrate dehydrogenase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Mus musculus | |
NADPH | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | ischemia-reperfusion reduces IDH2 expression and activity in both Idh2+/+ and Idh2-/- kidneys. IDH1 expression decreases 1 day after ischemia and then returns to around normal level by 16 days after ischemia | down |
General Information | Comment | Organism |
---|---|---|
malfunction | mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency exacerbates mitochondrial and cell damage after kidney ischemia-reperfusion injury, Idh2 gene deletion exacerbates ROS production and oxidative stress after ischemia-reperfusion, and causes I/R-induced mitochondrial dysfunction and morphologic fragmentation, resulting in severe apoptosis in kidney tubule cells, it impairs reduction of NADP+ and GSSG within mitochondria | Mus musculus |
physiological function | mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate to 2-oxooglutarate, synthesizing NADPH, which is essential for mitochondrial redox balance | Mus musculus |