Literature summary for 1.1.1.42 extracted from

Leterrier, M.; Barroso, J.B.; Valderrama, R.; Begara-Morales, J.C.; Sanchez-Calvo, B.; Chaki, M.; Luque, F.; Vinegla, B.; Palma, J.M.; Corpas, F.J.
Peroxisomal NADP-isocitrate dehydrogenase is required for Arabidopsis stomatal movement (2016), Protoplasma, 253, 403-415.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene pICDH, DNA and amino acid sequence determination and analysis, phylogenetic analysis	Arabidopsis thaliana

Protein Variants

Protein Variants	Comment	Organism
additional information	identification of naturally occurring peroxisomal NADP-ICDH (picdh) Arabidopsis mutant lines, designated as picdh-1 (SALK_072422) and picdh-2 (SALK_039193C) carrying a T-DNA insertion in exons 9 and in the 5'UTR, respectively. The mutation results in a lack of the peroxisomal NADP-ICDH in both picdh-1 and picdh-2 plants. There are no significant differences in phenotype between the wild-type (Wt) and the two mutant (picdh-1 and picdh-2) lines. Intrinsic photosynthetic performance is not altered in the different plants with similar maximum C assimilation capacities, light use efficiency, and respiration rates in darkness due to similar growth rates. No differences are found in growth rates, stomatal densities, or leaf mass-area ratios	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	-	Arabidopsis thaliana	5777	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
isocitrate + NADP+	Arabidopsis thaliana	-	2-oxoglutarate + CO2 + NADPH + H+	-	r
isocitrate + NADP+	Arabidopsis thaliana Col-0	-	2-oxoglutarate + CO2 + NADPH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q9SLK0	-	-
Arabidopsis thaliana Col-0	Q9SLK0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Arabidopsis thaliana	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
isocitrate + NADP+	-	Arabidopsis thaliana	2-oxoglutarate + CO2 + NADPH + H+	-	r
isocitrate + NADP+	-	Arabidopsis thaliana Col-0	2-oxoglutarate + CO2 + NADPH + H+	-	r

Synonyms

Synonyms	Comment	Organism
NADP-ICDH	-	Arabidopsis thaliana
NADP-isocitrate dehydrogenase	-	Arabidopsis thaliana

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Arabidopsis thaliana
NADPH	-	Arabidopsis thaliana

General Information

General Information	Comment	Organism
evolution	Arabidopsis thaliana has three NADP-ICDH genes At1g65930, At5g14590, and At1g54340, coding for the proteins NP_176768, NP_196963, and BT025983, respectively, that are located in different subcellular compartments, i.e. cytosol, chloroplasts, mitochondria, and peroxisomes	Arabidopsis thaliana

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Release 2023.1 (January 2023)