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Literature summary for 1.1.1.44 extracted from

  • Pearse, B.M.F.; Harris, J.I.
    6-Phosphogluconate dehydrogenase from Bacillus stearothermophilus (1973), FEBS Lett., 38, 49-52.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Geobacillus stearothermophilus

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide
-
Geobacillus stearothermophilus
iodoacetamide
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
2 * 50000, SDS-PAGE Geobacillus stearothermophilus
100000
-
-
Cyberlindnera jadinii
100000
-
sedimentation equilibrium Geobacillus stearothermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Homo sapiens
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Geobacillus stearothermophilus
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Geobacillus stearothermophilus NCA 1503
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Cyberlindnera jadinii
-
-
-
Geobacillus stearothermophilus
-
NCA 1503
-
Geobacillus stearothermophilus NCA 1503
-
NCA 1503
-
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
-
Geobacillus stearothermophilus

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Geobacillus stearothermophilus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Geobacillus stearothermophilus NCA 1503 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r

Subunits

Subunits Comment Organism
dimer
-
Cyberlindnera jadinii
dimer
-
Homo sapiens
dimer 2 * 50000, SDS-PAGE Geobacillus stearothermophilus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
-
Geobacillus stearothermophilus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 70 retains full activity at 60°C Geobacillus stearothermophilus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
stable at relatively high temperatures Geobacillus stearothermophilus