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Literature summary for 1.1.1.44 extracted from
- 6-Phospho-D-gluconate dehydrogenase from sheep liver (1975), Methods Enzymol., 41, 214-220.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Ovis aries |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2'-AMP | - |
Ovis aries |  |
| 3'-AMP | - |
Ovis aries | |
| ATP | - |
Ovis aries | |
| CDP | - |
Ovis aries | |
| citrate | - |
Ovis aries | |
| CMP | - |
Ovis aries | |
| CTP | - |
Ovis aries | |
| D-fructose 1,6-diphosphate | - |
Ovis aries | |
| D-Fructose 1-phosphate | - |
Ovis aries | |
| D-fructose 6-phosphate | - |
Ovis aries | |
| D-glucose 6-phosphate | - |
Ovis aries | |
| diphosphate | - |
Ovis aries | |
| GDP | - |
Ovis aries | |
| GMP | - |
Ovis aries | |
| GTP | - |
Ovis aries | |
| IDP | - |
Ovis aries | |
| IMP | - |
Ovis aries | |
| ITP | - |
Ovis aries | |
| oxaloacetate | - |
Ovis aries | |
| phosphate | - |
Ovis aries | |
| TDP | - |
Ovis aries | |
| TMP | - |
Ovis aries | |
| TTP | - |
Ovis aries | |
| UDP | - |
Ovis aries | |
| UMP | - |
Ovis aries | |
| UTP | - |
Ovis aries | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00022 | - |
NADPH | - |
Ovis aries | |
| 0.0068 | - |
NADP+ | - |
Ovis aries | |
| 0.0069 | - |
6-phosphogluconate | - |
Ovis aries | |
| 0.02 | - |
ribulose-5-phosphate | - |
Ovis aries | |
| 0.03 | - |
NADP+ | - |
Ovis aries | |
| 0.29 | - |
6-phosphogluconate | - |
Ovis aries | |
| 34 | - |
CO2 | - |
Ovis aries | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 94000 | - |
gel filtration, sedimentation equlibrium | Ovis aries |
| 129000 | - |
presence of impurities | Ovis aries |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phospho-D-gluconate + NADP+ | Rattus norvegicus | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | Ovis aries | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
sheep | - |
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
- |
Ovis aries |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| liver | - |
Ovis aries | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 18.7 | - |
ultrafiltration | Ovis aries |
| 19 | - |
pure enzyme | Ovis aries |
| 21 | - |
- |
Ovis aries |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phospho-D-gluconate + NADP+ | - |
Rattus norvegicus | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | - |
Ovis aries | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| D-ribulose 5-phosphate + CO2 + NADPH | - |
Ovis aries | 6-phospho-D-gluconate + NADP+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Rattus norvegicus |
| dimer | - |
Ovis aries |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Rattus norvegicus | |
| NADP+ | does not utilize NAD+ | Ovis aries | |
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Release 2023.1 (January 2023)
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