Application | Comment | Organism |
---|---|---|
medicine | 6-phosphogluconate dehydrogenase is a potential target for new drugs against African trypanosomiasis | Trypanosoma brucei |
Crystallization (Comment) | Organism |
---|---|
- |
Trypanosoma brucei |
crystal structures of recombinant Lactococcus lactis 6-phosphogluconate dehydrogenase in complex with substrate, cofactor, product and inhibitors | Lactococcus lactis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-phospho-D-erythronate | mimics the transition state of dehydrogenation. The inhibitor forces the catalytic lysine 185 into the protonated state | Trypanosoma brucei | |
4-phospho-D-erythronohydroxamic acid | - |
Lactococcus lactis | |
5-phospho-D-ribonate | substrate analogue | Trypanosoma brucei |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00013 | - |
6-phospho-D-gluconate | - |
Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Lactococcus lactis | P96789 | - |
- |
Trypanosoma brucei | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Lactococcus lactis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | - |
Trypanosoma brucei | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphogluconate dehydrogenase | - |
Trypanosoma brucei |
LlPDH | - |
Lactococcus lactis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00013 | - |
4-phospho-D-erythronate | - |
Trypanosoma brucei | |
0.00095 | - |
5-phospho-D-ribonate | - |
Trypanosoma brucei |