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Literature summary for 1.1.1.49 extracted from

  • Zhang, Z.; Liew, C.W.; Handy, D.E.; Zhang, Y.; Leopold, J.A.; Hu, J.; Guo, L.; Kulkarni, R.N.; Loscalzo, J.; Stanton, R.C.
    High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis (2010), FASEB J., 24, 1497-1505.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.49

Inhibitors

Inhibitors Comment Organism Structure
glucose high glucose level of 25 mM leads to a decrease in G6PD activity and protein level in islets Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
MIN-6 cell
-
 Mus musculus
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pancreatic islet high glucose level of 25 mM leads to a decrease in G6PD activity and protein level in islets Homo sapiens
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Expression

Organism Comment Expression
Mus musculus high glucose level inhibits G6PD expression down
Homo sapiens high glucose level inhibits G6PD expression down

General Information

General Information Comment Organism
metabolism high glucose level of 25 mM leads to a decrease in G6PD activity and protein level in islets. Inhibition of G6PD with siRNA leads to increase in reactive oxygen species and apoptosis, decreased proliferation, and impaired insulin secretion. High glucose level decreases insulin secretion, which is improved by overexpressing G6PD Homo sapiens
physiological function G6PD-deficient mice have smaller islets and impaired glucose tolerance compared with control mice, which suggests that G6PD deficiency per se leads to beta-cell dysfunction and death Mus musculus