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Literature summary for 1.1.1.51 extracted from

  • Mindnich, R.; Haller, F.; Halbach, F.; Moeller, G.; Hrabe de Angelis, M.; Adamski, J.
    Androgen metabolism via 17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme (2005), J. Mol. Endocrinol., 35, 305-316.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, phylogenetic tree, transient expression in HEK-293 cells Homo sapiens
DNA and amino acid sequence determination and analysis, phylogenetic tree, transient expression in zf4 cells Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
endoplasmic reticulum
-
Danio rerio 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
androstenedione + NADPH + H+ Homo sapiens
-
testosterone + NADP+
-
r
androstenedione + NADPH + H+ Danio rerio
-
testosterone + NADP+
-
r
additional information Homo sapiens evolutionary considerations ?
-
?
additional information Danio rerio evolutionary considerations ?
-
?

Organism

Organism UniProt Comment Textmining
Danio rerio Q6QA32
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo enzyme expression during embryogenesis from sphere to 84 h post-fertilization Danio rerio
-
HEK-293 cell low expression level Homo sapiens
-
liver highest enzyme expression in male liver Danio rerio
-
additional information expression in female and male tissues, sexual dimorphism, no activity in zf4 cells Danio rerio
-
ovary highest enzyme expression in female ovaries Danio rerio
-
testis almost exclusively Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH i.e. 11beta-hydroxy-androstenedione, reduction at C17 Homo sapiens 11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+ i.e. 11beta-testosterone ?
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH i.e. 11beta-hydroxy-androstenedione, reduction at C17 Danio rerio 11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+ i.e. 11beta-testosterone ?
androst-5-ene-3,11,17-trione + NADPH i.e. 11-keto-androstenedione, reduction at C17 Danio rerio 17beta-hydroxyandrost-5-ene-3,11-dione + NADP+ i.e. 11-keto-testosterone ?
androst-5-ene-3,11,17-trione + NADPH i.e. 11-ketoandrostenedione, reduction at C17 Homo sapiens 17beta-hydroxyandrost-5-ene-3,11-dione + NADP+ i.e. 11-keto-testosterone ?
androstanedione + NADPH reduction at C17 Homo sapiens dihydrotestosterone + NADP+
-
?
androstenedione + NADPH + H+
-
Homo sapiens testosterone + NADP+
-
r
androstenedione + NADPH + H+
-
Danio rerio testosterone + NADP+
-
r
androstenedione + NADPH + H+ the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview Homo sapiens testosterone + NADP+
-
r
androstenedione + NADPH + H+ the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview Danio rerio testosterone + NADP+
-
r
androsterone + NADPH + H+ reduction at C17 Homo sapiens androstane-3beta,17beta-diol + NADP+
-
?
dehydroepiandrosterone + NADPH + H+ reduction at C17 Homo sapiens 5-androstene-3beta,17beta-diol + NADP+
-
?
dehydroepiandrosterone + NADPH + H+ reduction at C17 Danio rerio 5-androstene-3beta,17beta-diol + NADP+
-
?
epiandrosterone + NADPH reduction at C17 Danio rerio androstane-3beta,17beta-diol + NADP+
-
?
epiandrosterone + NADPH reduction at C17 Homo sapiens 5-androstane-3beta,17beta-diol + NADP+
-
?
additional information evolutionary considerations Homo sapiens ?
-
?
additional information evolutionary considerations Danio rerio ?
-
?
additional information no activity with androstanedione and androsterone Danio rerio ?
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD type 3
-
Homo sapiens
17beta-HSD type 3
-
Danio rerio
17beta-hydroxysteroid dehydrogenase type 3
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase type 3
-
Danio rerio

Cofactor

Cofactor Comment Organism Structure
additional information no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview Homo sapiens
additional information no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview Danio rerio
NADP+
-
Homo sapiens
NADP+
-
Danio rerio
NADPH
-
Homo sapiens
NADPH
-
Danio rerio