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Literature summary for 1.1.1.51 extracted from

  • Ngatcha, B.T.; Laplante, Y.; Labrie, F.; Luu-The, V.; Poirier, D.
    3beta-Alkyl-androsterones as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines (2006), Mol. Cell. Endocrinol., 248, 225-232.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
3beta-cyclohexylethyl-androsterone
-
 Homo sapiens
3beta-hexyl-androsterone
-
 Homo sapiens
3beta-phenyl-androsterone mixed-type inhibition, shows some proliferative activity on AR+ and Er+ cell lines not mediated through androgen or estrogen receptors Homo sapiens
3beta-phenylethyl-androsterone
-
 Homo sapiens
3beta-phenylmethyl-androsterone mixed-type inhibition, shows some proliferative activity on AR+ and Er+ cell lines not mediated through androgen or estrogen receptors Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
androst-4-ene-3,17-dione + NADPH Homo sapiens
-
 testosterone + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androst-4-ene-3,17-dione + NADPH
-
 Homo sapiens testosterone + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
17beta-HSD
-
 Homo sapiens
type 3 17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens