Any feedback?
Literature summary for 1.1.1.51 extracted from
- Cloning, expression and characterization of three types of 17beta-hydroxysteroid dehydrogenases from the Nile tilapia, Oreochromis niloticus (2005), J. Mol. Endocrinol., 35, 103-116.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isozyme DNA and amino acid sequence determination and analysis, tissue-specific expression and phylogenetic analysis, expression of tissue-specific isozymes 17beta-HSD1 and 17beta-HSD8 in Escherichia coli and in HEK-293 cells | Oreochromis niloticus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Oreochromis niloticus | the enzyme plays a role in gonadal steroidogenesis | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oreochromis niloticus | - |
Nile tilapia, tissue-specific isozymes 17beta-HSD1 and 17beta-HSD8 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | isozyme 17beta-HSD8 | Oreochromis niloticus | - |
| gill | isozyme 17beta-HSD8 | Oreochromis niloticus | - |
| gonad | isozyme 17beta-HSD8 | Oreochromis niloticus | - |
| heart | isozyme 17beta-HSD8 | Oreochromis niloticus | - |
| intestine | isozyme 17beta-HSD8 | Oreochromis niloticus | - |
| kidney | isozyme 17beta-HSD8 | Oreochromis niloticus | - |
| liver | isozyme 17beta-HSD8 | Oreochromis niloticus | - |
| additional information | three tissue-specific isozymes, 17beta-HSD1 and 17beta-HSD8 | Oreochromis niloticus | - |
| muscle | isozyme 17beta-HSD8 | Oreochromis niloticus | - |
| ovary | isozyme 17beta-HSD1, predominantly | Oreochromis niloticus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| androstenedione + NADPH + H+ | isozymes 17beta-HSD1 and 17beta-HSD8 | Oreochromis niloticus | testosterone + NADP+ | - |
r | |
| additional information | the enzyme plays a role in gonadal steroidogenesis | Oreochromis niloticus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 17beta-hydroxysteroid dehydrogenase | - |
Oreochromis niloticus |
| More | cf. 1.1.1.62 | Oreochromis niloticus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Oreochromis niloticus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Oreochromis niloticus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Oreochromis niloticus | |
| NADPH | - |
Oreochromis niloticus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
