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Literature summary for 1.1.1.53 extracted from

  • Ohno, S.; Nakajin, S.; Shinoda, M.
    20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: 3alpha/beta-hydroxysteroid dehydrogenase activities catalyzed by highly purified enzyme (1991), J. Steroid Biochem. Mol. Biol., 38, 787-794.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cd2+
-
Sus scrofa
Cu2+
-
Sus scrofa
Fe2+
-
Sus scrofa
Hg2+
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00015
-
progesterone reduction Sus scrofa
0.00016
-
5alpha-pregnane-3,20-dione reduction Sus scrofa
0.00018
-
5alpha-androstan-17beta-ol-3-one reduction Sus scrofa
0.00032
-
5alpha-Androstan-3alpha-ol-17-one oxidation Sus scrofa
0.00094
-
17alpha-hydroxyprogesterone reduction Sus scrofa
7.2
-
beta-NADPH
-
Sus scrofa
14.8
-
beta-NADP+
-
Sus scrofa
88.2
-
beta-NAD+
-
Sus scrofa
126.1
-
alpha-NADH
-
Sus scrofa
294.8
-
beta-NADH
-
Sus scrofa
328
-
alpha-NADPH
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.003
-
purified enzyme, NADPH, progesterone Sus scrofa
0.019
-
purified enzyme, NADPH, 5beta-androstan-3alpha,17beta-diol oxidation Sus scrofa
0.023
-
purified enzyme, NADPH, dehydroisoandrosterone Sus scrofa
0.025
-
purified enzyme, NADPH, 5alpha-androstan-3alpha-ol-17-one oxidation Sus scrofa
0.046
-
purified enzyme, NADPH, 5alpha-androstan-17beta-ol-3-one Sus scrofa
0.051
-
purified enzyme, NADPH, 5alpha-pregnane-3,20-dione Sus scrofa
0.052
-
purified enzyme, NADPH, 5alpha-androstan-3alpha,17beta-diol oxidation Sus scrofa
0.091
-
purified enzyme, NADPH, 17alpha-methyl-5alpha-androstan-17beta-ol-3-one Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxyprogesterone + NADPH + H+
-
Sus scrofa 17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
?
5alpha-androstan-17beta-ol-3-one + NAD(P)H + H+ i.e. 5alpha-dihydrotestosterone Sus scrofa 5alpha-androstan-3alpha,17beta-diol + NAD(P)+ ratio 4:3 ?
5alpha-androstan-3alpha-ol-17-one + alpha-NAD+
-
Sus scrofa 5alpha-dihydrotestosterone + alpha-NADH + H+
-
r
5alpha-androstan-3alpha-ol-17-one + beta-NAD+
-
Sus scrofa 5alpha-dihydrotestosterone + beta-NADH + H+
-
r
5alpha-androstane-3,17-dione + NADPH
-
Sus scrofa ?
-
?
5alpha-dihydrotestosterone + alpha-NADH + H+
-
Sus scrofa 5alpha-androstan-3alpha-ol-17-one + alpha-NAD+
-
r
5alpha-dihydrotestosterone + alpha-NADPH + H+
-
Sus scrofa 5alpha-androstan-3alpha-ol-17-one + alpha-NADP+
-
r
5alpha-dihydrotestosterone + beta-NADH + H+
-
Sus scrofa 5alpha-androstan-3alpha-ol-17-one + beta-NAD+
-
r
5alpha-pregnane-3,20-dione + NADPH
-
Sus scrofa ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
reduction of 5alpha-androstan-17beta-ol-3-one with beta-NADPH Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
4.5 9
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Sus scrofa
NADH
-
Sus scrofa
NADP+
-
Sus scrofa
NADPH hydrogen transfer is stereospecific Sus scrofa