Literature summary for 1.1.1.62 extracted from

Mendoza-Hernandez, G.; Lopez-Solache, I.; Diaz-Zagoya, J.C.
Periodate-oxidized NADP+ is a powerful inhibitor of human placental estradiol-17beta dehydrogenase (1987), Biochem. Biophys. Res. Commun., 146, 645-651.

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Inhibitors

Inhibitors	Comment	Organism	Structure
EM-139	-	Homo sapiens
NADP+	strong inhibitor of NAD+-linked activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
placenta	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
estradiol-17beta + NAD+	-	Homo sapiens	estrone + NADH	-	r
estradiol-17beta + NADP+	-	Homo sapiens	estrone + NADPH	-	r
estrone + NADH	-	Homo sapiens	estradiol-17beta + NAD+	-	r
estrone + NADPH + H+	-	Homo sapiens	estradiol-17beta + NADP+	-	r

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	cofactor	Homo sapiens
NADH	cofactor	Homo sapiens
NADP+	cofactor	Homo sapiens
NADPH	cofactor	Homo sapiens

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Release 2023.1 (January 2023)