Application | Comment | Organism |
---|---|---|
medicine | attractive drug target in hormone-sensitive breast cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gossypol | and derivatives of gossypol, competitive with respect to NAD+ in reverse reaction | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H | Homo sapiens | final step in the synthesis of active estrogens | estradiol-17beta + NAD(P)+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
17beta-HSD1 | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H | - |
Homo sapiens | estradiol-17beta + NAD(P)+ | - |
r | |
estrone + NAD(P)H | final step in the synthesis of active estrogens | Homo sapiens | estradiol-17beta + NAD(P)+ | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |