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Literature summary for 1.1.1.62 extracted from

  • Lukacik, P.; Kavanagh, K.L.; Oppermann, U.
    Structure and function of human 17beta-hydroxysteroid dehydrogenases (2006), Mol. Cell. Endocrinol., 248, 61-71.
    View publication on PubMed

Application

Application Comment Organism
drug development several 17beta-HSD isozymes are targets for drug development with importance in cancer, metabolic diseases, neurodegeneration and possibly immunity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
chromosomal localizations of isozymes, DNA and amino acid sequence determination and analysis of isozymes 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, overview Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
17beta-HSD14 in ternary complex with NADP+ and estradiol, modelling Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum isozymes 17beta-HSD2, 17beta-HSD3, and 17beta-HSD7 Homo sapiens 5783
-
mitochondrion isozyme 17beta-HSD10 Homo sapiens 5739
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soluble isozyme 17beta-HSD14, 17beta-HSD5, and 17beta-HSD1 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NADPH Homo sapiens the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites 17beta-estradiol + NADP+
-
r
estronesulfate + NADPH Homo sapiens
-
17beta-estradiolsulfate + NADP+
-
r
additional information Homo sapiens the isozymes constitute by showing different properties a complex system ensuring cell-specific adaptation and regulation of sex steroid hormone levels, isozyme 17beta-HSD1 is the major determinant of peripheral and gonadal estradiol synthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
several isozymes, encoded by different genes
-

Reaction

Reaction Comment Organism Reaction ID
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ active site structure of isozymes 17beta-HSD1 and 17beta-HSD14 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
gonad
-
Homo sapiens
-
liver 17beta-HSD8 Homo sapiens
-
ovary 17beta-HSD8 in cumulus cells, not in granulosa and luteal cells, vice versa for isozymes 17beta-HSD1 and 17beta-HSD7 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + NADPH the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites Homo sapiens 17beta-estradiol + NADP+
-
r
estrone + NADPH substrate of e.g. isozyme 17beta-HSD3, 17beta-HSD8, and 17beta-HSD14 Homo sapiens 17beta-estradiol + NADP+
-
r
estronesulfate + NADPH
-
Homo sapiens 17beta-estradiolsulfate + NADP+
-
r
additional information the isozymes constitute by showing different properties a complex system ensuring cell-specific adaptation and regulation of sex steroid hormone levels, isozyme 17beta-HSD1 is the major determinant of peripheral and gonadal estradiol synthesis Homo sapiens ?
-
?
additional information 17beta-HSD isozymes differ in their expression pattern, nucleotide cofactor preferences, steroid substrate specificity, and subcellular localization, detailed overview, substrate are androgens, estrogens, cholesterol, progestins, and eicosanoids, isozyme 17beta-HSD3 also shows 3beta-hydroxysteroid dehydrogenase, EC 1.1.1.51, isozyme 17beta-HSD8 also shows, to a lessser extent, NAD+-dependent testosterone oxidation to androstenedione, EC 1.1.1.63 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase
-
Homo sapiens
More 17beta-HSDs belong to the aldo-keto reductase family or the short-chain dehydrogenase family, overview Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens