Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(13alpha)-3-hydroxyestra-1(10),2,4-trien-17-one | inhibits the enzyme activity effectively, enzyme affinity is similar to that of the natural estrone substrate | Homo sapiens | |
3-hydroxy-13alpha-D-secooxime | displays an outstanding cofactor dependence, i.e. more efficient inhibition in the presence of NADH than NADPH | Homo sapiens | |
3-hydroxy-13beta-D-secoalcohol | displays an outstanding cofactor dependence, i.e. more efficient inhibition in the presence of NADH than NADPH | Homo sapiens | |
D-secoalcohol estrone | - |
Homo sapiens | |
D-secooxime | - |
Homo sapiens | |
additional information | inhibitory effects of 13-epimeric estrones, D-secooxime and D-secoalcohol estrone compounds on placental enzyme 17beta-HSD1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14061 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD1 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00007 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-hydroxy-13alpha-D-secooxime | |
0.0012 | - |
pH and temperature not specified in the publication | Homo sapiens | (13alpha)-3-hydroxyestra-1(10),2,4-trien-17-one |