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Literature summary for 1.1.1.80 extracted from
- Gas chromatographic study of the histochemical reaction for isopropanol dehydrogenase (1979), J. Chromatogr., 172, 374-378.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | characterization of adrenal and gonadal tissue | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00024 | - |
ethanol | - |
Rattus norvegicus |  |
| 0.00071 | - |
4-Methyl-1-pentanol | - |
Rattus norvegicus | |
| 0.00178 | - |
propan-2-ol | - |
Rattus norvegicus | |
| 0.00259 | - |
6-methyl-2-heptanol | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | activity detected in mitochondria and cytoplasm | Rattus norvegicus | 5737 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | possibly takes part in the further metabolic reactions of the fragments formed from the side-chain of the steroid hormone precursor in the adrenals or gonads | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methyl-1-pentanol + NAD+ | - |
Rattus norvegicus | 4-methyl-1-pentanal + NADH | - |
? | |
| 4-methyl-1-pentanol + NADP+ | - |
Rattus norvegicus | 4-methyl-1-pentanal + NADPH | - |
? | |
| 6-methyl-2-heptanol + NAD+ | - |
Rattus norvegicus | 6-methyl-2-heptanone + NADH + H+ | - |
? | |
| 6-methyl-2-heptanol + NADP+ | - |
Rattus norvegicus | 6-methyl-2-heptanone + NADPH | - |
? | |
| ethanol + NAD+ | - |
Rattus norvegicus | ethanal + NADH | - |
? | |
| ethanol + NADP+ | - |
Rattus norvegicus | ethanal + NADPH + H+ | - |
? | |
| additional information | also acts on short-chain secondary alcohols and, slowly, on primary alcohols | Rattus norvegicus | ? | - |
? | |
| additional information | possibly takes part in the further metabolic reactions of the fragments formed from the side-chain of the steroid hormone precursor in the adrenals or gonads | Rattus norvegicus | ? | - |
? | |
| propan-2-ol + NAD+ | NAD+ effectively substitutes for NADP+ | Rattus norvegicus | acetone + NADH | - |
? | |
| propan-2-ol + NADP+ | - |
Rattus norvegicus | acetone + NADPH | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.4 | 7 | in mitochondria | Rattus norvegicus |
| 8.2 | - |
in cytoplasma | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 8.6 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | effectively substitutes for NADP+ | Rattus norvegicus | |
| NADP+ | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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