Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-hydroxy-3-methylglutarate | competitive inhibitor | Pseudomonas mevalonii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.032 | - |
NADH | reductive deacylation to mevalonate | Pseudomonas mevalonii | |
0.039 | - |
CoA | oxidative acylation of mevalonate | Pseudomonas mevalonii | |
0.046 | - |
CoA | mevaldate oxidation | Pseudomonas mevalonii | |
0.05 | - |
DL-3-hydroxy-3-methylglutaryl-CoA | reductive deacylation to mevalonate | Pseudomonas mevalonii | |
0.06 | - |
NAD+ | mevaldate oxidation | Pseudomonas mevalonii | |
0.27 | - |
NAD+ | oxidative acylation of mevalonate | Pseudomonas mevalonii | |
0.3 | - |
mevalonate | oxidative acylation of mevalonate | Pseudomonas mevalonii | |
0.36 | - |
NADH | mevaldate reduction to mevalonate | Pseudomonas mevalonii | |
0.61 | - |
DL-mevaldate | mevaldate oxidation | Pseudomonas mevalonii | |
9 | - |
DL-mevaldate | mevaldate reduction to mevalonate | Pseudomonas mevalonii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
270000 | - |
SDS-PAGE | Pseudomonas mevalonii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas mevalonii | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Pseudomonas mevalonii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NAD+ | with mevalonate as sole source of carbon enzyme acts as a biodegradative enzyme | Pseudomonas mevalonii | (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
r | |
3-hydroxy-3-methylglutaryl-CoA + NADH + H+ | - |
Pseudomonas mevalonii | mevalonate + CoA + NAD+ | - |
? | |
DL-mevaldate + CoA + NAD+ | - |
Pseudomonas mevalonii | 4-hydroxy-3-methylglutaryl-CoA NADH + H+ | - |
r | |
DL-mevaldate + CoA + NAD+ | - |
Pseudomonas mevalonii | 5-hydroxy-3-methylglutaryl-CoA NADH + H+ | - |
r | |
additional information | oxidative acylation of mevalonate: the carboxy-, 3-methyl-, and 3-hydroxy groups are essential for substrate binding to the enzyme | Pseudomonas mevalonii | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Pseudomonas mevalonii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.1 | - |
assay conditions | Pseudomonas mevalonii |
9.2 | 9.6 | oxidative acylation of mevalonate | Pseudomonas mevalonii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Pseudomonas mevalonii | |
NADH | reverse reaction | Pseudomonas mevalonii |