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Literature summary for 1.1.1.95 extracted from

  • Albers, E.; Laize, V.; Blomberg, A.; Hohmann, S.; Gustafsson, L.
    Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae (2003), J. Biol. Chem., 278, 10264-10272.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-phosphoglycerate + NAD+ Saccharomyces cerevisiae the enzyme catalyzes the first reaction of serine and glycine biosynthesis. SER3 and SER33 encode phosphoglycerate dehydrogenases. The requirement for the SER-dependent phosphoglycerate pathway is conditional since the glyoxylate route of serine/glycine biosynthesis is glucose repressed. Ser33p is likely to be the main isoenzyme of the phosphoglycerate pathway during growth on glucose 3-phosphohydroxypyruvate + NADH
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phosphoglycerate + NAD+
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Saccharomyces cerevisiae 3-phosphohydroxypyruvate + NADH
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3-phosphoglycerate + NAD+ the enzyme catalyzes the first reaction of serine and glycine biosynthesis. SER3 and SER33 encode phosphoglycerate dehydrogenases. The requirement for the SER-dependent phosphoglycerate pathway is conditional since the glyoxylate route of serine/glycine biosynthesis is glucose repressed. Ser33p is likely to be the main isoenzyme of the phosphoglycerate pathway during growth on glucose Saccharomyces cerevisiae 3-phosphohydroxypyruvate + NADH
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Cofactor

Cofactor Comment Organism Structure
NAD+
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Saccharomyces cerevisiae