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Literature summary for 1.1.1.95 extracted from

  • Peters-Wendisch, P.; Stolz, M.; Etterich, H.; Kennerknecht, N.; Sahm, H.; Eggeling, L.
    Metabolic engineering of Corynebacterium glutamicum for L-serine production (2005), Appl. Environ. Microbiol., 71, 7139-7144.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
biotechnology metabolic engineering of Corynebacterium glutamicum for L-serine production by enzyme overexpression Corynebacterium glutamicum
synthesis metabolic engineering of Corynebacterium glutamicum for L-serine production by enzyme overexpression Corynebacterium glutamicum

Cloned(Commentary)

Cloned (Comment) Organism
gene serA, overexpression in Escherichia coli strains DH5alphaMCR and GM2929, co-overexpression of serA with other enzymes of the L-serine biosynthesis pathway leads to increased L-serine production in Corynebacterium glutamicum mutant serADELAT197 Corynebacterium glutamicum

Protein Variants

Protein Variants Comment Organism
additional information construction of an L-serine-insensitive mutant serADELAT197 Corynebacterium glutamicum

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Corynebacterium glutamicum
L-serine feedback regulation of the wild-type enzyme Corynebacterium glutamicum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-phospho-D-glycerate + NAD+ Corynebacterium glutamicum first step in biosynthesis of L-serine, pathway regulation, overview 3-phosphohydroxypyruvate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum
-
gene serA, ATCC 13032
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phospho-D-glycerate + NAD+
-
Corynebacterium glutamicum 3-phosphohydroxypyruvate + NADH
-
?
3-phospho-D-glycerate + NAD+ first step in biosynthesis of L-serine, pathway regulation, overview Corynebacterium glutamicum 3-phosphohydroxypyruvate + NADH
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Corynebacterium glutamicum

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Corynebacterium glutamicum