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Literature summary for 1.1.1.B40 extracted from

  • Basu, R.; Edgerton, D.S.; Singh, R.J.; Cherrington, A.; Rizza, R.A.
    Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity (2006), Diabetes, 55, 3013-3019.
    View publication on PubMed
Search for more literature for 1.1.1.B40

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NAD+ Canis lupus familiaris pathway overview cortisone + NADH
-
 ir

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Canis lupus familiaris
-
hepatocyte primary Canis lupus familiaris
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liver hepatic artery, portal vein, and hepatic vein, local cortisol concentrations, overview Canis lupus familiaris
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viscus splanchnic activity Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 splanchnic, visceral, and hepatic net cortisol balance, cortisol uptake, and cortisol production, overview Canis lupus familiaris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NAD+ pathway overview Canis lupus familiaris cortisone + NADH
-
 ir

Synonyms

Synonyms Comment Organism
11beta hydroxysteroid dehydrogenase type 2
-
 Canis lupus familiaris
isozyme 11beta-HSD2
-
 Canis lupus familiaris

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Canis lupus familiaris