Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for inhibitor design and development | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells | Rattus norvegicus |
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells | Mesocricetus auratus |
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells | Homo sapiens |
expression of isozyme 11beta-HSD1 in HEK-293 cells | Cavia porcellus |
isozyme 11beta-HSD1, expression in HEK-293 cells | Mus musculus |
isozyme 11beta-HSD1, expression in HEK-293 cells | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-hydroxyflavanone | - |
Canis lupus familiaris | |
2'-hydroxyflavanone | - |
Cavia porcellus | |
2'-hydroxyflavanone | - |
Homo sapiens | |
2'-hydroxyflavanone | - |
Mesocricetus auratus | |
2'-hydroxyflavanone | - |
Mus musculus | |
2'-hydroxyflavanone | - |
Rattus norvegicus | |
abietic acid | - |
Canis lupus familiaris | |
abietic acid | - |
Cavia porcellus | |
abietic acid | - |
Homo sapiens | |
abietic acid | - |
Mesocricetus auratus | |
abietic acid | - |
Mus musculus | |
abietic acid | - |
Rattus norvegicus | |
carbenoxolone | - |
Canis lupus familiaris | |
carbenoxolone | - |
Cavia porcellus | |
carbenoxolone | - |
Homo sapiens | |
carbenoxolone | - |
Mesocricetus auratus | |
carbenoxolone | - |
Mus musculus | |
carbenoxolone | - |
Rattus norvegicus | |
chenodeoxycholic acid | - |
Canis lupus familiaris | |
chenodeoxycholic acid | - |
Cavia porcellus | |
chenodeoxycholic acid | - |
Homo sapiens | |
chenodeoxycholic acid | - |
Mesocricetus auratus | |
chenodeoxycholic acid | - |
Mus musculus | |
chenodeoxycholic acid | - |
Rattus norvegicus | |
flavanone | - |
Canis lupus familiaris | |
flavanone | - |
Cavia porcellus | |
flavanone | - |
Homo sapiens | |
flavanone | - |
Mesocricetus auratus | |
flavanone | - |
Mus musculus | |
flavanone | - |
Rattus norvegicus | |
glycyrrhetinic acid | - |
Canis lupus familiaris | |
glycyrrhetinic acid | - |
Cavia porcellus | |
glycyrrhetinic acid | - |
Homo sapiens | |
glycyrrhetinic acid | - |
Mesocricetus auratus | |
glycyrrhetinic acid | - |
Mus musculus | |
glycyrrhetinic acid | - |
Rattus norvegicus | |
additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Canis lupus familiaris | |
additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Cavia porcellus | |
additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Homo sapiens | |
additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Mesocricetus auratus | |
additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Mus musculus | |
additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Rattus norvegicus | |
T0504 | - |
Canis lupus familiaris | |
T0504 | - |
Cavia porcellus | |
T0504 | - |
Homo sapiens | |
T0504 | - |
Mesocricetus auratus | |
T0504 | - |
Mus musculus | |
T0504 | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00038 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Mus musculus | |
0.00042 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Homo sapiens | |
0.00043 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Cavia porcellus | |
0.00045 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Mesocricetus auratus | |
0.00052 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Mus musculus | |
0.00052 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Homo sapiens | |
0.00057 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Mesocricetus auratus | |
0.00057 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Canis lupus familiaris | |
0.00064 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Cavia porcellus | |
0.00085 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Rattus norvegicus | |
0.00136 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Rattus norvegicus | |
0.00157 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Canis lupus familiaris |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Cavia porcellus |
33000 | - |
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Mus musculus |
33000 | - |
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Rattus norvegicus |
33000 | - |
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Mesocricetus auratus |
35000 | - |
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Canis lupus familiaris |
35000 | - |
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH | Mus musculus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | Rattus norvegicus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | Canis lupus familiaris | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | Mesocricetus auratus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | Homo sapiens | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | Cavia porcellus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
cortisol + NAD+ | Homo sapiens | isozyme 11beta-HSD2 | cortisone + NADH | - |
ir | |
cortisone + NADPH + H+ | Mus musculus | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Rattus norvegicus | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Canis lupus familiaris | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Mesocricetus auratus | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Cavia porcellus | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
poodle, isozyme 11beta-HSD1 | - |
Cavia porcellus | Q6QLL4 | isozyme 11beta-HSD1; gene HSD11B1, isozyme 11beta-HSD1 | - |
Homo sapiens | P28845 | isozyme 11beta-HSD2; isozyme 11beta-HSD2 | - |
Homo sapiens | P80365 | isozyme 11beta-HSD1; isozyme 11beta-HSD1 | - |
Mesocricetus auratus | Q6R0J2 | isozyme 11beta-HSD1; isozyme 11beta-HSD1 | - |
Mus musculus | - |
isozyme 11beta-HSD1 | - |
Rattus norvegicus | - |
isozyme 11beta-HSD1 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Mus musculus | |
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Rattus norvegicus | |
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Canis lupus familiaris | |
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Mesocricetus auratus | |
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Homo sapiens | |
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Cavia porcellus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Canis lupus familiaris | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
additional information | - |
- |
Rattus norvegicus |
additional information | - |
- |
Canis lupus familiaris |
additional information | - |
- |
Mesocricetus auratus |
additional information | - |
- |
Homo sapiens |
additional information | - |
- |
Cavia porcellus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Mus musculus | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Rattus norvegicus | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Canis lupus familiaris | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Mesocricetus auratus | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Homo sapiens | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Cavia porcellus | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1, low activity | Canis lupus familiaris | corticosterone + NADP+ | - |
? | |
2 7-oxocholesterol + 2 NADPH + 2 H+ | isozyme 11beta-HSD1, stereospecific reaction | Mesocricetus auratus | 7beta-hydroxycholesterol + 7alpha-hydroxycholesterol + 2 NADP+ | - |
? | |
7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction | Mus musculus | 7beta-hydroxycholesterol + NADP+ | - |
? | |
7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction | Rattus norvegicus | 7beta-hydroxycholesterol + NADP+ | - |
? | |
7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction | Homo sapiens | 7beta-hydroxycholesterol + NADP+ | - |
? | |
7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction, very low activity | Canis lupus familiaris | 7beta-hydroxycholesterol + NADP+ | - |
? | |
7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction, very low activity | Cavia porcellus | 7beta-hydroxycholesterol + NADP+ | - |
? | |
cortisol + NAD+ | isozyme 11beta-HSD2 | Homo sapiens | cortisone + NADH | - |
ir | |
cortisol + NAD+ | isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+ | Homo sapiens | cortisone + NADH | - |
ir | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Mus musculus | cortisol + NADP+ | - |
r | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Rattus norvegicus | cortisol + NADP+ | - |
r | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Mus musculus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Rattus norvegicus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Canis lupus familiaris | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Mesocricetus auratus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Homo sapiens | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Cavia porcellus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, high activity | Mesocricetus auratus | cortisol + NADP+ | - |
r | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, high activity | Cavia porcellus | cortisol + NADP+ | - |
r | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, low activity | Canis lupus familiaris | cortisol + NADP+ | - |
r | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, preferred substrate, high activity | Homo sapiens | cortisol + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
? | x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Cavia porcellus |
? | x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Mus musculus |
? | x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Rattus norvegicus |
? | x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Mesocricetus auratus |
? | x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Canis lupus familiaris |
? | x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Homo sapiens |
More | structure molecular modeling | Mus musculus |
More | structure molecular modeling | Rattus norvegicus |
More | structure molecular modeling | Canis lupus familiaris |
More | structure molecular modeling | Mesocricetus auratus |
More | structure molecular modeling | Homo sapiens |
More | structure molecular modeling | Cavia porcellus |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Mus musculus |
11beta-HSD1 | - |
Rattus norvegicus |
11beta-HSD1 | - |
Canis lupus familiaris |
11beta-HSD1 | - |
Mesocricetus auratus |
11beta-HSD1 | - |
Homo sapiens |
11beta-HSD1 | - |
Cavia porcellus |
11beta-HSD2 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Canis lupus familiaris |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Mesocricetus auratus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Cavia porcellus |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
7-alpha-HCD | - |
Mesocricetus auratus |
7-alpha-hydroxycholesterol dehydrogenase | - |
Mesocricetus auratus |
corticosteroid 11-beta-dehydrogenase isozyme 1 | - |
Mesocricetus auratus |
corticosteroid 11-beta-dehydrogenase isozyme 1 | - |
Cavia porcellus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Canis lupus familiaris |
37 | - |
assay at | Mesocricetus auratus |
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Cavia porcellus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Rattus norvegicus |
7.4 | - |
assay at | Canis lupus familiaris |
7.4 | - |
assay at | Mesocricetus auratus |
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
assay at | Cavia porcellus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADP+ | - |
Mus musculus | |
NADP+ | - |
Rattus norvegicus | |
NADP+ | - |
Canis lupus familiaris | |
NADP+ | - |
Mesocricetus auratus | |
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Cavia porcellus | |
NADPH | - |
Mus musculus | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Canis lupus familiaris | |
NADPH | - |
Mesocricetus auratus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Cavia porcellus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000006 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
0.000015 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
0.000025 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
0.000025 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
0.000028 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
0.00008 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
0.000082 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
0.00011 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
0.00012 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
0.00012 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
0.00023 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
0.00023 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
0.00025 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
0.00028 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
0.00029 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
0.0003 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
0.00033 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
0.00034 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
0.00035 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
0.00043 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
0.00044 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
0.00055 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
0.00059 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
0.00077 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
0.00094 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
0.0012 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
0.0018 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
0.002 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
0.0021 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
0.0021 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
0.0021 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
0.0025 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
0.003 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
0.0039 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
0.0049 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
0.0049 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
0.0052 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
0.0061 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
0.0064 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
0.007 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
0.007 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
0.0097 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
0.011 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
0.015 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
0.017 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
0.019 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
0.02 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
0.031 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
0.031 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
0.034 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
0.035 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
0.035 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
0.05 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
0.054 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
0.2 | - |
flavanone | above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
0.2 | - |
2'-hydroxyflavanone | above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens |