Literature summary for 1.1.1.B52 extracted from

Zhang, W.X.; Xu, G.C.; Huang, L.; Pan, J.; Yu, H.L.; Xu, J.H.
Highly efficient synthesis of (R)-3-quinuclidinol in a space-time yield of 916 g L(-1) d(-1) using a new bacterial reductase ArQR (2013), Org. Lett., 15, 4917-4919.

Search for more literature for 1.1.1.B52

Application

Application	Comment	Organism
pharmacology	stereospecific production of (R)-3-quinuclidinol, an important chiral building block for the synthesis of various pharmaceuticals, high yield of (R)-3-quinuclidinol up to 916 g/L * d using a bioreduction approach	Agrobacterium tumefaciens
synthesis	stereospecific production of (R)-3-quinuclidinol, an important chiral building block for the synthesis of various pharmaceuticals, high yield of (R)-3-quinuclidinol up to 916 g/L * d using a bioreduction approach	Agrobacterium tumefaciens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Agrobacterium tumefaciens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.4	-	3-quinuclidinone	pH 7.0, temperature not specified in the publication	Agrobacterium tumefaciens

Organism

Organism	UniProt	Comment	Textmining
Agrobacterium tumefaciens	G1K3P5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-quinuclidinone + NADH + H+	high activity and excellent enantioselectivity	Agrobacterium tumefaciens	(R)-3-quinuclidinol + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
ArQR	-	Agrobacterium tumefaciens

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
290	-	3-quinuclidinone	pH 7.0, temperature not specified in the publication	Agrobacterium tumefaciens

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Release 2023.1 (January 2023)