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Literature summary for 1.1.3.15 extracted from

  • de Bari, L.; Valenti, D.; Atlante, A.; Passarella, S.
    L-lactate generates hydrogen peroxide in purified rat liver mitochondria due to the putative L-lactate oxidase localized in the intermembrane space (2010), FEBS Lett., 584, 2285-2290.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NAD+ competitive Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0052
-
(S)-lactate pH 7.4, 25°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial intermembrane space exclusively Rattus norvegicus 5758
-
additional information subcellular localization analysis, no enzyme activity in cytosol, mitochondrial membrane, or mitochondrial matrix, overview Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactate + O2 Rattus norvegicus
-
pyruvate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme, subcellular fractionation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + O2
-
Rattus norvegicus pyruvate + H2O2
-
?

Synonyms

Synonyms Comment Organism
L-LAC-OX
-
Rattus norvegicus
L-lactate oxidase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 9 L-LAC-OX activity is rather constant in 6.0-9.0 pH range Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FMN dependent on Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.03
-
NAD+ pH 7.4, 25°C Rattus norvegicus