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Literature summary for 1.1.3.17 extracted from
- On the contribution of the positively charged headgroup of choline to substrate binding and catalysis in the reaction catalyzed by choline oxidase (2006), Arch. Biochem. Biophys., 451, 182-187.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics and thermodynamics, steady state kinetic mechanism | Arthrobacter globiformis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| choline + O2 | Arthrobacter globiformis | - |
betaine aldehyde + H2O2 | - |
? |  |
| FADH2 + O2 | Arthrobacter globiformis | - |
FAD + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arthrobacter globiformis | - |
strain ATCC 8010 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| choline + O2 = betaine aldehyde + H2O2 | steady state kinetic mechanism, the enzyme catalyzes the four-electron-oxidation of choline to glycine betaine via the intermediate betaine aldehyde in two sequential FAD-dependent reaction steps, detailed reaction mechanism | Arthrobacter globiformis |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
pH-dependent catalytic efficiency, overview | Arthrobacter globiformis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,3-dimethylbutan-1-ol + O2 | 10fold lower activity compared to choline | Arthrobacter globiformis | ? | - |
? | |
| choline + O2 | - |
Arthrobacter globiformis | betaine aldehyde + H2O2 | - |
? | |
| FADH2 + O2 | - |
Arthrobacter globiformis | FAD + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CHO | - |
Arthrobacter globiformis |
| COX | - |
Arthrobacter globiformis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Arthrobacter globiformis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Arthrobacter globiformis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pH-dependent catalytic efficiency, overview | Arthrobacter globiformis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | dependent on, covalently bound to the enzyme | Arthrobacter globiformis | |
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Release 2023.1 (January 2023)
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