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Literature summary for 1.1.99.B7 extracted from
- Purification and characterization of a membrane-bound enzyme complex from the sulfate-reducing archaeon Archaeoglobus fulgidus related to heterodisulfide reductase from methanogenic archaea (2002), Eur. J. Biochem., 269, 1895-1904.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | membrane-bound enzyme complex | Archaeoglobus fulgidus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron-sulfur cluster | contains [4Fe-4S]+ clusters | Archaeoglobus fulgidus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 16700 | - |
x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE | Archaeoglobus fulgidus |
| 30500 | - |
x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE | Archaeoglobus fulgidus |
| 38000 | - |
x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE | Archaeoglobus fulgidus |
| 64400 | - |
x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE | Archaeoglobus fulgidus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Archaeoglobus fulgidus | the enzyme plays a key role in the energy metabolism of methanogenic archaea | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Archaeoglobus fulgidus | O29751 and O29749 and O29748 and O29747 | O29751: extracytoplasmic iron-sulfur protein 1 (Hme subunit A), O29749: Hdr-like menaquinol oxidoreductase cytochrome b-like subunit (Hme subunit C), O29748: Hdr-like menaquinol oxidoreductase iron-sulfur subunit 2 (Hme subunit D), O29747: Hdr-like menaquinol oxidoreductase cytochrome c subunit (Hme subunit E) | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Archaeoglobus fulgidus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-dimethyl-1,4-naphthoquinone + reduced coenzyme F420 | - |
Archaeoglobus fulgidus | 2,3-dimethyl-1,4-naphthoquinol + oxidized coenzyme F420 | - |
? | |
| additional information | the enzyme plays a key role in the energy metabolism of methanogenic archaea | Archaeoglobus fulgidus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| oligomer | x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE | Archaeoglobus fulgidus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Hme complex | - |
Archaeoglobus fulgidus |
| menaquinol oxidoreductase | - |
Archaeoglobus fulgidus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | heme/iron-sulfur protein. The heme groups of the enzyme are rapidly reduced by reduced 2,3-dimethyl-1,4-naphthoquinone, which indicates that the enzyme functions as a menaquinol-acceptor oxidoreductase | Archaeoglobus fulgidus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays a key role in the energy metabolism of methanogenic archaea | Archaeoglobus fulgidus |
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