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Literature summary for 1.11.1.12 extracted from
- Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice (2008), Free Radic. Biol. Med., 44, 343-352.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | overexpression of GPx4 inhibits the development of atherosclerosis by decreasing lipid peroxidation and inhibiting the sensitivity of vascular cells to oxidized lipids | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transgenic mice overexpressing human GPx4 are generated | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| selenium | - |
Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 21000 | - |
20 to 22 kDa | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + a lipid hydroperoxide | Homo sapiens | - |
glutathione disulfide + lipid + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | transgenic mouse | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + a lipid hydroperoxide | - |
Homo sapiens | glutathione disulfide + lipid + H2O | - |
? | |
| glutathione + phosphatidylcholine hydroperoxide | activity assay | Homo sapiens | ? | - |
? | |
| additional information | GPx4 can react with H2O2 and a wide range of lipid hydroperoxides including oxidized phospholipids and cholesterol hydroperoxides | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione peroxidase-4 | - |
Homo sapiens |
| GPx4 | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
activity assay | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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