Literature summary for 1.11.1.13 extracted from

Wang, J.; Ogata, M.; Hirai, H.; Kawagishi, H.
Detoxification of aflatoxin B1 by manganese peroxidase from the white-rot fungus Phanerochaete sordida YK-624 (2011), FEMS Microbiol. Lett., 314, 164-169.

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Application

Application	Comment	Organism
degradation	enzyme is able to detoxify aflatoxin B1. Maximum elimination of 86.0% of aflatoxin B1 is observed after 48 h in a reaction mixture containing 5 nkat of enzyme, and the addition of Tween 80 enhances elimination. The treatment of aflatoxin B1 by 20 nkat MnP reduces the mutagenic activity by 69.2%. Analysis suggests that aflatoxin B1 is first oxidized to aflatoxin B1-8,9-epoxide and then hydrolyzed to aflatoxin B1-8,9-dihydrodiol	Phanerochaete sordida

Organism

Organism	UniProt	Comment	Textmining
Phanerochaete sordida	-	-	-
Phanerochaete sordida YK-624	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 Mn2+ + H2O2 + aflatoxin B1	maximum elimination of 86.0% of aflatoxin B1 is observed after 48 h in a reaction mixture containing 5 nkat of enzyme, and the addition of Tween 80 enhances elimination. The treatment of aflatoxin B1 by 20 nkat MnP reduces the mutagenic activity by 69.2%. Analysis suggests that aflatoxin B1 is first oxidized to aflatoxin B1-8,9-epoxide and then hydrolyzed to aflatoxin B1-8,9-dihydrodiol	Phanerochaete sordida	2 Mn3+ + aflatoxin B1-8,9-dihydrodiol	-	?
2 Mn2+ + H2O2 + aflatoxin B1	maximum elimination of 86.0% of aflatoxin B1 is observed after 48 h in a reaction mixture containing 5 nkat of enzyme, and the addition of Tween 80 enhances elimination. The treatment of aflatoxin B1 by 20 nkat MnP reduces the mutagenic activity by 69.2%. Analysis suggests that aflatoxin B1 is first oxidized to aflatoxin B1-8,9-epoxide and then hydrolyzed to aflatoxin B1-8,9-dihydrodiol	Phanerochaete sordida YK-624	2 Mn3+ + aflatoxin B1-8,9-dihydrodiol	-	?

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Release 2023.1 (January 2023)