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Literature summary for 1.11.1.18 extracted from

  • Hartung, J.; Dumont, Y.; Greb, M.; Hach, D.; Koehler, F.; Schulz, H.; Casny, M.; Rehder, D.; Vilter, H.
    On the reactivity of bromoperoxidase I (Ascophyllum nodosum) in buffered organic media: Formation of carbon bromine bonds (2009), Pure Appl. Chem., 81, 1251-1264.
No PubMed abstract available

General Stability

General Stability Organism
activity half-life times increase along the series of buffers: phosphate Ascophyllum nodosum

Organism

Organism UniProt Comment Textmining
Ascophyllum nodosum
-
-
-

Storage Stability

Storage Stability Organism
20°C, in 0.001 mM H2O2-incubated, MES-buffered (pH 6.22) aqueous alcoholic solution, half-life time of about 60 days Ascophyllum nodosum
20°C, in 0.001 mM NaCl-incubated, MES-buffered (pH 6.22) aqueous alcoholic solution, half-life time of about 24 days Ascophyllum nodosum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Br- + H2O2 + (3R)-3-bromo-2,6-dimethylhept-5-en-2-ol
-
Ascophyllum nodosum 3,5-dibromo-2,6-dimethylheptane-2,6-diol + H2O 70% yield, at pH 6.0 ?
Br- + H2O2 + 1-phenylpent-4-en-1-ol
-
Ascophyllum nodosum 4-bromo-1-phenylpentane-1,5-diol + 5-bromo-1-phenylpentane-1,4-diol + 2-(bromomethyl)-5-phenyltetrahydrofuran + H2O 30% yield of 4-bromo-1-phenylpentane-1,5-diol, 28% yield of 5-bromo-1-phenylpentane-1,4-diol, and 25% yield of 2-(bromomethyl)-5-phenyltetrahydrofuran, at pH 6.0 ?
Br- + H2O2 + 5-methyl-1-phenylhex-4-en-1-ol
-
Ascophyllum nodosum 4-bromo-5-methyl-1-phenylhexane-1,5-diol + 2-(1-bromo-1-methylethyl)-5-phenyltetrahydrofuran + 3-bromo-2,2-dimethyl-6-phenyltetrahydro-2H-pyran + H2O 69% yield of 4-bromo-5-methyl-1-phenylhexane-1,5-diol, 6% yield of 2-(1-bromo-1-methylethyl)-5-phenyltetrahydrofuran, and 9% yield of 3-bromo-2,2-dimethyl-6-phenyltetrahydro-2H-pyran, at pH 6.0 ?
Br- + H2O2 + methyl pyrrole-2-carboxylate
-
Ascophyllum nodosum methyl 5-amino-4-bromocyclopenta-1,3-diene-1-carboxylate + methyl 5-amino-3-bromocyclopenta-1,3-diene-1-carboxylate + methyl 5-amino-3,4-dibromocyclopenta-1,3-diene-1-carboxylate + H2O 5% yield of methyl 5-amino-4-bromocyclopenta-1,3-diene-1-carboxylate, 59% yield of methyl 5-amino-3-bromocyclopenta-1,3-diene-1-carboxylate, and 5% yield of methyl 5-amino-3,4-dibromocyclopenta-1,3-diene-1-carboxylate, at pH 6.3 and 25°C ?
Br- + H2O2 + monochlorodimedone
-
Ascophyllum nodosum H2O + ?
-
?
I- + H2O2
-
Ascophyllum nodosum triiodide + ?
-
?

Synonyms

Synonyms Comment Organism
BPO I
-
Ascophyllum nodosum
bromoperoxidase I
-
Ascophyllum nodosum
EC 1.11.1.10 formerly Ascophyllum nodosum
vanadate-dependent bromoperoxidase I
-
Ascophyllum nodosum
VBrPO(AnI)
-
Ascophyllum nodosum

Cofactor

Cofactor Comment Organism Structure
additional information the enzyme does require no additional cofactor Ascophyllum nodosum