Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the periplasmic enzyme is dependent on the twin-arginine target protein KapA for activity | Helicobacter pylori |
Cloned (Comment) | Organism |
---|---|
- |
Helicobacter pylori |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a mutant strain with a Thr501-truncated KatA and a KapA-deficient mutant strain, only the latter shows 5.5fold reduced KatA activity in the periplasm, the cytoplasmic activities remain unaltered in all cases, site-directed mutagenesis | Helicobacter pylori |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | enzyme is produced in the cytoplasm and transported into the periplasm by a Sec-independent enzyme transport, the enzyme contains no signal peptide at the N-terminus | Helicobacter pylori | 5737 | - |
periplasm | enzyme is produced in the cytoplasm and transported into the periplasm by a Sec-independent enzyme transport, the enzyme contains no signal peptide at the N-terminus | Helicobacter pylori | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2O2 | Helicobacter pylori | enzyme is responsible for the protection of the Helicobacter pylori cells against phagocyte attack in the gastric mucosa by disumtation of H2O2 | O2 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | - |
gene katA, enzyme KatA | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | no signal peptide at the N-terminus | Helicobacter pylori |
Purification (Comment) | Organism |
---|---|
native enzyme from cytoplasm and cell envelope | Helicobacter pylori |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2O2 | - |
Helicobacter pylori | O2 + H2O | - |
? | |
H2O2 | enzyme is responsible for the protection of the Helicobacter pylori cells against phagocyte attack in the gastric mucosa by disumtation of H2O2 | Helicobacter pylori | O2 + H2O | - |
? | |
additional information | the enzyme contains a unique tetra-lysine motif at the C-terminus which probably is required for interaction with protein KapA | Helicobacter pylori | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | determination and analysis of secondary enzyme structure | Helicobacter pylori |
Synonyms | Comment | Organism |
---|---|---|
KatA | - |
Helicobacter pylori |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Helicobacter pylori |