Literature summary for 1.11.1.8 extracted from

Dubska, M.; Banga, J.P.; Plochocka, D.; Hoser, G.; Kemp, E.H.; Sutton, B.J.; Gardas, A.; Gora, M.
Structural insights into autoreactive determinants in thyroid peroxidase composed of discontinuous and multiple key contact amino acid residues contributing to epitopes recognized by patients autoantibodies (2006), Endocrinology, 147, 5995-6003.

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Application

Application	Comment	Organism
medicine	R646 and D707 together with R225 constitute a functional epitope within IDR-A, and that residues E604, D620, and D630, together with K627, constitute a functional epitope within IDR-B. The identification of key residues within the autoreactive epitopes will help in understanding the structural basis for the breakdown of immune tolerance to TPO in thyroid autoimmune disease	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thyroid gland	-	Homo sapiens	-

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Release 2023.1 (January 2023)