Literature summary for 1.11.1.8 extracted from

Palazzolo, D.L.; Jansen, K.P.
The minimal arsenic concentration required to inhibit the activity of thyroid peroxidase activity in vitro (2008), Biol. Trace Elem. Res., 126, 49-55.

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Inhibitors

Inhibitors	Comment	Organism	Structure
arsenic trioxide	0.1 ppm arsenic trioxide has no effect on TPO activity, incubation for 2 min in the presence of 1.0, 5.0, or 10 ppm arsenic trioxide inhibits TPO activity to 4%, 9%, and 9% of control, respectively. After 10 min incubation in the presence of 1.0 or 5.0 ppm arsenic trioxide, TPO activity returns to 92% and 54% of control, respectively, while the presence of 10 ppm arsenic trioxide further inhibits TPO activity to 1% of control	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
iodide + H2O2	-	Homo sapiens	iodine + H2O	-	?

Synonyms

Synonyms	Comment	Organism
thyroid peroxidase	-	Homo sapiens
TPO	-	Homo sapiens

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Release 2023.1 (January 2023)