Application | Comment | Organism |
---|---|---|
medicine | the enzyme has potential therapeutic value as an antioxidant, but its pharmacological development is limited because the enzyme uses a selenocysteine as its catalytic group and it is difficult to generate selenium-containing proteins with traditional recombinant DNA technology | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the enzyme has potential therapeutic value as an antioxidant, but its pharmacological development is limited because the enzyme uses a selenocysteine as its catalytic group and it is difficult to generate selenium-containing proteins with traditional recombinant DNA technology. Rat theta-class glutathione transferase T2-2 (rGST T2-2) presents an ideal scaffold for the design of a novel glutathione peroxidase catalyst because it binds GSH and contains a serine close to substrate binding site, which can be chemically modified to bind selenium. The modified Se-rGST T2-2 efficiently catalyzes the reduction of hydrogen peroxide, and the glutathione peroxidase activity surpasses the activities of some natural glutathione peroxidases | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2O2 + GSH | Rattus norvegicus | the enzyme protects cells against oxidative damage | H2O + GSSG | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
rat theta-class glutathione transferase T2-2 (rGST T2-2) presents an ideal scaffold for the design of a novel glutathione peroxidase catalyst because it binds GSH and contains a serine close to substrate binding site, which can be chemically modified to bind selenium. The modified Se-rGST T2-2 efficiently catalyzes the reduction of hydrogen peroxide, and the glutathione peroxidase activity surpasses the activities of some natural glutathione peroxidases | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2O2 + GSH | the enzyme protects cells against oxidative damage | Rattus norvegicus | H2O + GSSG | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GPX | - |
Rattus norvegicus |