Application | Comment | Organism |
---|---|---|
medicine | in liver, by 24 h, exposure to alow dose of Cd causes 13% loss of Gpx4a expression. At higher dose, Cd leads to 40% decrease in Gpx4a expression. Longer exposure periods cause about 20% loss of liver Gpx4a expression by low Cd dose | Oncorhynchus kisutch |
medicine | olfactory isoform Gpx4b mRNA expression is not extensively modulated by presence of cadmium ions. In liver, by 24 h, exposure to alow dose of Cd causes 18% loss of Gpx4b expression. At higher dose, Cd leads to 37% decrease in Gpx4b expression. Longer exposure periods cause about 22% loss of liver Gpx4b expression by low Cd dose, whereas at higher Cd exposures, a 33% loss in Gpx4b expression is observed | Oncorhynchus kisutch |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | higher GPx activities are observed in cytosolic fractions than mitochondrial fractions in both the olfactory and liver tissues | Oncorhynchus kisutch | 5829 | - |
mitochondrion | higher GPx activities are observed in cytosolic fractions than mitochondrial fractions in both the olfactory and liver tissues | Oncorhynchus kisutch | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
cadmium | in liver, by 24 h, exposure to alow dose of Cd causes 13% loss of Gpx4a expression. At higher dose, Cd leads to 40% decrease in Gpx4a expression. Longer exposure periods cause about 20% loss of liver Gpx4a expression by low Cd dose | Oncorhynchus kisutch | |
cadmium | olfactory isoform Gpx4b mRNA expression is not extensively modulated by presence of cadmium ions. In liver, by 24 h, exposure to alow dose of Cd causes 18% loss of Gpx4b expression. At higher dose, Cd leads to 37% decrease in Gpx4b expression. Longer exposure periods cause about 22% loss of liver Gpx4b expression by low Cd dose, whereas at higher Cd exposures, a 33% loss in Gpx4b expression is observed | Oncorhynchus kisutch |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oncorhynchus kisutch | H9AZT5 | isoform Gpx4a | - |
Oncorhynchus kisutch | H9AZT6 | isoform Gpx4b | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain | Oncorhynchus kisutch | - |
heart | highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain | Oncorhynchus kisutch | - |
heart | highest mRNA expression in pyloric ceca, followed by brain, heart and liver | Oncorhynchus kisutch | - |
liver | highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain | Oncorhynchus kisutch | - |
liver | highest mRNA expression in pyloric ceca, followed by brain, heart and liver | Oncorhynchus kisutch | - |
additional information | in general, isoform Gpx4b mRNA expression exceeds that of isoform Gpx4a in all tissues with the exception of the pyloric caeca. The ratio of gpx4b/gpx4a is highest in ovary, and lowest in pyloric caeca | Oncorhynchus kisutch | - |
ovary | highest mRNA expression in ovary, followed by pyloric caeca, heart, liver and brain | Oncorhynchus kisutch | - |
pyloric cecum | highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain | Oncorhynchus kisutch | - |
pyloric cecum | highest mRNA expression in pyloric ceca, followed by brain, heart and liver | Oncorhynchus kisutch | - |
Synonyms | Comment | Organism |
---|---|---|
GPx4 | - |
Oncorhynchus kisutch |
Organism | Comment | Expression |
---|---|---|
Oncorhynchus kisutch | in liver, by 24 h, exposure to alow dose of Cd causes 13% loss of Gpx4a expression. At higher dose, Cd leads to 40% decrease in Gpx4a expression. Longer exposure periods cause about 20% loss of liver Gpx4a expression by low Cd dose | down |
Oncorhynchus kisutch | olfactory isoform Gpx4b mRNA expression is not extensively modulated by presence of cadmium ions. In liver, by 24 h, exposure to alow dose of Cd causes 18% loss of Gpx4b expression. At higher dose, Cd leads to 37% decrease in Gpx4b expression. Longer exposure periods cause about 22% loss of liver Gpx4b expression by low Cd dose, whereas at higher Cd exposures, a 33% loss in Gpx4b expression is observed | down |