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Literature summary for 1.11.1.9 extracted from

  • Wang, L.; Harris, S.M.; Espinoza, H.M.; McClain, V.; Gallagher, E.P.
    Characterization of phospholipid hydroperoxide glutathione metabolizing peroxidase (gpx4) isoforms in Coho salmon olfactory and liver tissues and their modulation by cadmium (2012), Aquat. Toxicol., 114-115, 134-141.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine in liver, by 24 h, exposure to alow dose of Cd causes 13% loss of Gpx4a expression. At higher dose, Cd leads to 40% decrease in Gpx4a expression. Longer exposure periods cause about 20% loss of liver Gpx4a expression by low Cd dose Oncorhynchus kisutch
medicine olfactory isoform Gpx4b mRNA expression is not extensively modulated by presence of cadmium ions. In liver, by 24 h, exposure to alow dose of Cd causes 18% loss of Gpx4b expression. At higher dose, Cd leads to 37% decrease in Gpx4b expression. Longer exposure periods cause about 22% loss of liver Gpx4b expression by low Cd dose, whereas at higher Cd exposures, a 33% loss in Gpx4b expression is observed Oncorhynchus kisutch

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol higher GPx activities are observed in cytosolic fractions than mitochondrial fractions in both the olfactory and liver tissues Oncorhynchus kisutch 5829
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mitochondrion higher GPx activities are observed in cytosolic fractions than mitochondrial fractions in both the olfactory and liver tissues Oncorhynchus kisutch 5739
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Metals/Ions

Metals/Ions Comment Organism Structure
cadmium in liver, by 24 h, exposure to alow dose of Cd causes 13% loss of Gpx4a expression. At higher dose, Cd leads to 40% decrease in Gpx4a expression. Longer exposure periods cause about 20% loss of liver Gpx4a expression by low Cd dose Oncorhynchus kisutch
cadmium olfactory isoform Gpx4b mRNA expression is not extensively modulated by presence of cadmium ions. In liver, by 24 h, exposure to alow dose of Cd causes 18% loss of Gpx4b expression. At higher dose, Cd leads to 37% decrease in Gpx4b expression. Longer exposure periods cause about 22% loss of liver Gpx4b expression by low Cd dose, whereas at higher Cd exposures, a 33% loss in Gpx4b expression is observed Oncorhynchus kisutch

Organism

Organism UniProt Comment Textmining
Oncorhynchus kisutch H9AZT5 isoform Gpx4a
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Oncorhynchus kisutch H9AZT6 isoform Gpx4b
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Source Tissue

Source Tissue Comment Organism Textmining
brain highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain Oncorhynchus kisutch
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heart highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain Oncorhynchus kisutch
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heart highest mRNA expression in pyloric ceca, followed by brain, heart and liver Oncorhynchus kisutch
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liver highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain Oncorhynchus kisutch
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liver highest mRNA expression in pyloric ceca, followed by brain, heart and liver Oncorhynchus kisutch
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additional information in general, isoform Gpx4b mRNA expression exceeds that of isoform Gpx4a in all tissues with the exception of the pyloric caeca. The ratio of gpx4b/gpx4a is highest in ovary, and lowest in pyloric caeca Oncorhynchus kisutch
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ovary highest mRNA expression in ovary, followed by pyloric caeca, heart, liver and brain Oncorhynchus kisutch
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pyloric cecum highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain Oncorhynchus kisutch
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pyloric cecum highest mRNA expression in pyloric ceca, followed by brain, heart and liver Oncorhynchus kisutch
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Synonyms

Synonyms Comment Organism
GPx4
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Oncorhynchus kisutch

Expression

Organism Comment Expression
Oncorhynchus kisutch in liver, by 24 h, exposure to alow dose of Cd causes 13% loss of Gpx4a expression. At higher dose, Cd leads to 40% decrease in Gpx4a expression. Longer exposure periods cause about 20% loss of liver Gpx4a expression by low Cd dose down
Oncorhynchus kisutch olfactory isoform Gpx4b mRNA expression is not extensively modulated by presence of cadmium ions. In liver, by 24 h, exposure to alow dose of Cd causes 18% loss of Gpx4b expression. At higher dose, Cd leads to 37% decrease in Gpx4b expression. Longer exposure periods cause about 22% loss of liver Gpx4b expression by low Cd dose, whereas at higher Cd exposures, a 33% loss in Gpx4b expression is observed down