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Literature summary for 1.11.2.1 extracted from

  • Knorrscheidt, A.; Soler, J.; Huenecke, N.; Puellmann, P.; Garcia-Borras, M.; Weissenborn, M.
    Simultaneous screening of multiple substrates with an unspecific peroxygenase enabled modified alkane and alkene oxyfunctionalisations (2021), Catal. Sci. Technol., 11, 6058-6064 .
No PubMed abstract available
Search for more literature for 1.11.2.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae Thermothelomyces thermophilus

Protein Variants

Protein Variants Comment Organism
A161L the mutant substantially diminishes the 4- and 3-octanol formation from octane while preserving the 2-octanol regioisomer formation as compared to the wild type enzyme Thermothelomyces thermophilus
F154V the mutant demonstrates 1.8fold improved turnover numbers for formation of the 4-octanol regioisomer relative to the wild type enzyme. Also, a 1.5 and 4fold decreased formation of 3- and 2-octanol, respectively, are observed Thermothelomyces thermophilus
L60A the mutation almost abolishes the octane transformation but keeps a significant cyclohexene oxide formation compared to the wild type enzyme Thermothelomyces thermophilus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ contains Mg2+ Thermothelomyces thermophilus

Organism

Organism UniProt Comment Textmining
Thermothelomyces thermophilus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(prop-1-en-2-yl)benzene + H2O2
-
 Thermothelomyces thermophilus 2-methyl-2-phenyloxirane + H2O
-
 ?
1-methylcyclohexene + H2O2
-
 Thermothelomyces thermophilus 1-methyl-7-oxabicyclo[4.1.0]heptane + H2O
-
 ?
cyclohexane + H2O2
-
 Thermothelomyces thermophilus cyclohexanol + 7-oxabicyclo[4.1.0]heptane + H2O
-
 ?
cyclohexene + H2O2
-
 Thermothelomyces thermophilus 7-oxabicyclo[4.1.0]heptane + H2O
-
 ?
ethenylbenzene + H2O2
-
 Thermothelomyces thermophilus 2-phenyloxirane + H2O
-
 ?
octane + H2O2
-
 Thermothelomyces thermophilus 3-octanol + 2-octanol + 4-octanol + H2O
-
 ?
[(1Z)-prop-1-en-1-yl]benzene + H2O2
-
 Thermothelomyces thermophilus (2Z)-3-phenylprop-2-en-1-ol + (2Z)-3-phenylprop-2-enal + H2O
-
 ?

Synonyms

Synonyms Comment Organism
UPO
-
 Thermothelomyces thermophilus

Cofactor

Cofactor Comment Organism Structure
heme
-
 Thermothelomyces thermophilus