Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-thio-2-nitrobenzoic acid | competitive inhibitor of myeloperoxidase | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
thiocyanate | in 100 mM phosphate buffer, pH 7.4, at 21°C | Homo sapiens | |
2 | - |
Br- | in 100 mM phosphate buffer, pH 7.4, at 21°C | Homo sapiens | |
175 | - |
Cl- | in 100 mM phosphate buffer, pH 7.4, at 21°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
15500 | - |
SDS-PAGE under reducing conditions gives three bands with molecular masses of 57000, 39000 and 15000 Da, respectively | Homo sapiens |
39000 | - |
SDS-PAGE under reducing conditions gives three bands with molecular masses of 57000, 39000 and 15000 Da, respectively | Homo sapiens |
57000 | - |
SDS-PAGE under reducing conditions gives three bands with molecular masses of 57000, 39000 and 15000 Da, respectively | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 + H+ | Homo sapiens | physiological substrate of myeloperoxidase | HClO + H2O | - |
? | |
thiocyanate + H2O2 + H+ | Homo sapiens | thiocyanate is a major physiological substrate of myeloperoxidase and most favoured substrate compared to chloride and bromide | hypothiocyanite + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Br- + H2O2 + H+ | - |
Homo sapiens | HBrO + H2O | - |
? | |
Cl- + H2O2 + H+ | - |
Homo sapiens | HClO + H2O | - |
? | |
Cl- + H2O2 + H+ | physiological substrate of myeloperoxidase | Homo sapiens | HClO + H2O | - |
? | |
I- + H2O2 + H+ | - |
Homo sapiens | HIO + H2O | - |
? | |
thiocyanate + H2O2 + H+ | thiocyanate is a major physiological substrate of myeloperoxidase and most favoured substrate compared to chloride and bromide | Homo sapiens | hypothiocyanite + H2O | - |
? | |
thiocyanate + H2O2 + H+ | thiocyanate is the most favoured substrate compared to chloride and bromide. With 0.1 mM thiocyanate about 50% of the H2O2 present is converted into hypothiocyanite, the rate of H2O2 loss catalysed by myeloperoxidase in the presence of 100 mM chloride doubles when 0.1 mM thiocyanate is added, and is maximal with 1 mM thiocyanate | Homo sapiens | hypothiocyanite + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MPO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |