Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Sodium azide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 | - |
Homo sapiens | HClO + H2O | - |
? | |
additional information | in the presence of the complete MPO/H2O2/Cl- system, lyso-products and chlorohydrins are only formed at pH values lower than pH 6.0 with an optimum at pH 4.3 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
donor:hydrogen peroxide oxidoreductase | - |
Homo sapiens |
MPO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | hypochlorite formed by the MPO-H2O2-Cl- system is responsible for modification in unsaturated phosphatidylcholines (e.g. 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2arachidonoyl-sn-glycero-3-phosphocholine, 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine, or 1-palmitoyl-2-docosahexenoyl-sn-glycero-3-phosphocholine). The formation of lysophospholipids and chlorohydrins from unsaturated phosphatidylcholines by myeloperoxidase can be relevant in vivo under acute inflammatory conditions | Homo sapiens |