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Literature summary for 1.12.99.6 extracted from

  • Pinske, C.; McDowall, J.S.; Sargent, F.; Sawers, R.G.
    Analysis of hydrogenase 1 levels reveals an intimate link between carbon and hydrogen metabolism in Escherichia coli K-12 (2012), Microbiology, 158, 856-868.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli P0ACD8 large subunit HyaB
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Escherichia coli P69739 small subunit HyaA
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Synonyms

Synonyms Comment Organism
HyaA
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Escherichia coli
HyaB
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Escherichia coli
HYD1
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Escherichia coli

General Information

General Information Comment Organism
physiological function growth of a strain that lacks a functional fructose phosphotransferase system in the presence of fructose results in an approximately 10fold increase in isoform Hyd1 levels in comparison with growth under the same conditions with glucose. This increase in the amount of Hyd1 is not due to regulation at the transcriptional level. Reintroduction of a functional fructose phosphotransferase system restores growth on D-fructose and reduces Hyd1 levels to those observed after growth on D-glucose. Reducing the rate of glucose uptake by introducing a mutation in the gene encoding the cAMP receptor protein, or consumption through glycolysis, by introducing a mutation in phosphoglucose isomerase, increased Hyd1 levels during growth on glucose. Thus the ability to oxidize hydrogen by Hyd1 shows a strong correlation with the rate of carbon flow through glycolysis and provides a direct link between hydrogen, carbon and energy metabolism Escherichia coli