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Literature summary for 1.13.11.12 extracted from
- Evaluation of lipoxygenase inhibitory activity of anacardic acids (2008), Z. Naturforsch. C, 63, 539-546.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-dodecyl-6-hydroxybenzoic acid | C12:0, competitive inhibitor | Glycine max |  |
| 2-hydroxy-6-[(8E)-pentadec-8-en-1-yl]benzoic acid | C15:1, E-isomer, competitive inhibitor | Glycine max | |
| 6-(2'-ethylheptyl)salicylic acid | - |
Glycine max | |
| 6-(4',8'-dimethylnonyl) salicylic acid | - |
Glycine max | |
| 6-pentadecanylsalicylic acid | competitive inhibitor, dose-dependent inhibitory effect | Glycine max | |
| 6-[2'-(2'',4'',5''-trihydroxyphenyl)etyl]salicylic acid | inhibits lipoxygenase-catalyzed oxidation of linoleic acid, but to a lesser extent compared to 6-pentadecanylsalicylic acid | Glycine max | |
| 6-[2'-(2'',4''-dihydroxyphenyl)ethyl]salicylic acid | inhibits lipoxygenase-catalyzed oxidation of linoleic acid, but to a lesser extent compared to 6-pentadecanylsalicylic acid | Glycine max | |
| 6-[2'-(2'',5''-dihydroxyphenyl)ethyl]salicylic acid | inhibits lipoxygenase-catalyzed oxidation of linoleic acid, but to a lesser extent compared to 6-pentadecanylsalicylic acid | Glycine max | |
| 6-[2'-(3'',4''-dihydroxyphenyl)ethyl]salicylic acid | inhibits lipoxygenase-catalyzed oxidation of linoleic acid, but to a lesser extent compared to 6-pentadecanylsalicylic acid | Glycine max | |
| 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid | from Anacardium occidentale | Glycine max | |
| 6-[8(Z),11(Z)-pentadecadienyl]salicylic acid | from Anacardium occidentale | Glycine max | |
| 6-[8(Z)-pentadecenyl]salicylic acid | from Anacardium occidentale | Glycine max | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0117 | - |
linoleic acid | in the presence of 2-hydroxy-6-[(8E)-pentadec-8-en-1-yl]benzoic acid | Glycine max | |
| 0.0131 | - |
linoleic acid | in the presence of 6-pentadecanylsalicylic acid | Glycine max | |
| 0.0132 | - |
linoleic acid | in the presence of 2-dodecyl-6-hydroxybenzoic acid | Glycine max | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Glycine max | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| linoleic acid + O2 | - |
Glycine max | (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipoxygenase-1 | - |
Glycine max |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Glycine max |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0028 | - |
2-hydroxy-6-[(8E)-pentadec-8-en-1-yl]benzoic acid | pH 9.0 | Glycine max | |
| 0.0064 | - |
6-pentadecanylsalicylic acid | pH 9.0 | Glycine max | |
| 0.0096 | - |
2-dodecyl-6-hydroxybenzoic acid | pH 9.0 | Glycine max | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00207 | - |
pH 9.0 | Glycine max | 2-dodecyl-6-hydroxybenzoic acid | |
| 0.0068 | - |
pH 9.0 | Glycine max | 2-hydroxy-6-[(8E)-pentadec-8-en-1-yl]benzoic acid | |
| 0.0105 | - |
pH 9.0 | Glycine max | 6-(4',8'-dimethylnonyl) salicylic acid | |
| 0.0143 | - |
pH 9.0 | Glycine max | 6-pentadecanylsalicylic acid | |
| 0.0188 | - |
pH 9.0 | Glycine max | 6-(2'-ethylheptyl)salicylic acid | |
| 0.4 | - |
pH 9.0 | Glycine max | 6-[2'-(2'',5''-dihydroxyphenyl)ethyl]salicylic acid | |
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