Literature summary for 1.13.11.12 extracted from

Ha, T.J.; Shimizu, K.; Ogura, T.; Kubo, I.
Inhibition mode of soybean lipoxygenase-1 by quercetin (2010), Chem. Biodivers., 7, 1893-1903.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxybenzofuran-3(2H)-one	quercetin is slowly oxidized by hydroperoxides to a rather stable intermediate, 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxybenzofuran-3(2H)-one, which still inhibits the enzymatic oxidation, probably as a chelator	Glycine max
kaempferol	-	Glycine max
additional information	3,4-dihydro-7-hydroxycadalin, 7-hydroxycadalin, 3-hydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 3,4-dihydroxyphenylacetic acid do not inhibit the soybean lipoxygenase-1 catalyzed lipid peroxidation	Glycine max
quercetin	noncompetitive inhibition by initially reducing the ferric form of the enzyme to an inactive ferrous form	Glycine max
rutin	-	Glycine max

Organism

Organism	UniProt	Comment	Textmining
Glycine max	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
linoleate + O2	-	Glycine max	(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate	-	?

Synonyms

Synonyms	Comment	Organism
lipoxygenase-1	-	Glycine max

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0048	-	in 0.1M Tris-HCl (pH 8.0), at 25°C	Glycine max	quercetin

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Release 2023.1 (January 2023)