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Literature summary for 1.13.11.27 extracted from
- Steady state kinetics of 4-hydroxyphenylpyruvate dioxygenase from human liver (III) (1977), J. Biol. Chem., 252, 5094-5099.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-hydroxyphenylacetate | - |
Homo sapiens |  |
| 4-hydroxyphenylpyruvate | - |
Homo sapiens | |
| bathophenanthroline | - |
Homo sapiens | |
| diethyldithiocarbamate | - |
Homo sapiens | |
| homogentisate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
enzyme form 3 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 | enzyme form 3: ordered bi bi mechanism where 4-hydroxyphenylpyruvate is added prior to oxygen and CO2 released before homogentisate | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylpyruvate + O2 | - |
Homo sapiens | homogentisate + CO2 | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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