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Literature summary for 1.13.11.27 extracted from
- Assay, properties and tissue distribution of p-hydroxyphenylpyruvate hydroxylase (1972), Biochim. Biophys. Acta, 284, 90-100.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxyphenylpyruvate | - |
Rattus norvegicus |  |
| o-hydroxyphenylpyruvate | competitive inhibitor of 4-hydroxyphenylpyruvate | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
4-hydroxyphenylpyruvate | - |
Rattus norvegicus | |
| 0.05 | - |
3,4-Dihydroxyphenylpyruvate | - |
Rattus norvegicus | |
| 0.06 | - |
phenylpyruvate | - |
Rattus norvegicus | |
| 0.1 | - |
O2 | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Didelphidae | - |
- |
- |
| Oncorhynchus mykiss | - |
- |
- |
| Platyrrhini | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Platyrrhini | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oncorhynchus mykiss | - |
| liver | - |
Didelphidae | - |
| additional information | - |
Oncorhynchus mykiss | - |
| additional information | - |
Didelphidae | - |
| additional information | no activity detected in heart, muscle and brain | Rattus norvegicus | - |
| additional information | no activity detected in heart, muscle and brain | Platyrrhini | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
methods for assay | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-dihydroxyphenylpyruvate + O2 | - |
Rattus norvegicus | ? + CO2 | - |
? | |
| 4-hydroxyphenylpyruvate + O2 | - |
Rattus norvegicus | homogentisate + CO2 | - |
? | |
| 4-hydroxyphenylpyruvate + O2 | - |
Platyrrhini | homogentisate + CO2 | - |
? | |
| 4-hydroxyphenylpyruvate + O2 | - |
Oncorhynchus mykiss | homogentisate + CO2 | - |
? | |
| 4-hydroxyphenylpyruvate + O2 | - |
Didelphidae | homogentisate + CO2 | - |
? | |
| phenylpyruvate + O2 | - |
Rattus norvegicus | 2-hydroxyphenylacetate + CO2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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