Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ascorbate | required for activity | Streptomyces avermitilis | |
catalase | from bovine liver, required for activity | Streptomyces avermitilis |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Streptomyces avermitilis |
Protein Variants | Comment | Organism |
---|---|---|
F337I | 0.67 of wild-type activity | Streptomyces avermitilis |
F341Y | 16.9% of wild-type activity | Streptomyces avermitilis |
N216I | 0.15% of wild-type activity | Streptomyces avermitilis |
N216I/F337I | inactive | Streptomyces avermitilis |
N216I/F337I/F341Y | inactive | Streptomyces avermitilis |
N216I/F341Y | inactive | Streptomyces avermitilis |
P214T | 1.6% of wild-type activity | Streptomyces avermitilis |
P214T/F337I/F341Y | inactive | Streptomyces avermitilis |
P214T/N216I | inactive | Streptomyces avermitilis |
P214T/N216I/F337I | inactive | Streptomyces avermitilis |
P214T/N216I/F337I/F341Y | inactive | Streptomyces avermitilis |
P214T/N216I/F341Y | inactive | Streptomyces avermitilis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required for activity | Streptomyces avermitilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyphenylpyruvate + O2 | Streptomyces avermitilis | - |
homogentisate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces avermitilis | Q53586 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyphenylpyruvate + O2 | - |
Streptomyces avermitilis | homogentisate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HPD | - |
Streptomyces avermitilis |