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Literature summary for 1.13.11.31 extracted from

  • Yokoyama, C.; Mizuno, K.; Mitachi, H.; Yoshimoto, T.; Yamamoto, S.
    Partial purification and characterization of arachidonate 12-lipoxygenase from rat lung (1983), Biochim. Biophys. Acta, 750, 237-243.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5,8,11,14-Eicosatetraynoic acid 0.001 mM, 77% inhibition Rattus norvegicus
8-hydroxyquinoline 1 mM, 35% inhibition Rattus norvegicus
BW755C 0.01 mM, 13% inhibition Rattus norvegicus
EDTA 1 mM, 40% inhibition Rattus norvegicus
nordihydroguaiaretic acid 0.01 mM, 48% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
arachidonic acid
-
Rattus norvegicus
0.03
-
5,8,11,14,17-eicosapentaenoic acid
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol more than half of the activity Rattus norvegicus 5829
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.34
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
-70°C, 1 month, no appreciable loss of activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,8,11,14,17-eicosapentaenoic acid + O2
-
Rattus norvegicus 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid
-
?
arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Rattus norvegicus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
40
-
10 min, stable below Rattus norvegicus
45
-
10 min, 60% loss of activity Rattus norvegicus
50
-
10 min, 86% loss of activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.1 8.6 pH 6.1: 37% of maximal activity, pH 8.6: 44% of maximal activity Rattus norvegicus