Cloned (Comment) | Organism |
---|---|
gene alox15, expression analysis and genotyping of wild-type and iron-deficient mutant rats, gene alox15 doesnot respond to iron, transcription regulation via cytokines and growth factors, overview | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the enzyme is involved in production of biologically active lipid mediators, (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate, 13-HODE, and 13-HOTE, in the intestine of iron-deficient Belgrade rats, the lipids are almoste absent in wild-type rats, overview | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | dependent on | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Rattus norvegicus | the enzyme is involved in production of biologically active lipid mediators, (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate, 13-HODE, and 13-HOTE, in the intestine of iron-deficient rats, the lipids are almoste absent in wild-type rats, overview | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | further metabolized to (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q02759 | wild-type Sprague-Dawley rats and iron-deficient Belgrade rats, three isozymes: platelet, leukocyte, and epidermis isozyme, Alox15 is a leukocyte-type isozyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Rattus norvegicus | - |
epidermis | - |
Rattus norvegicus | - |
intestine | - |
Rattus norvegicus | - |
leukocyte | Alox15 | Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
additional information | the leukocyte-type isozyme is widely distributed in cell types, while the epidermis-type and the platelet-type isozymes are more limited | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Rattus norvegicus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | further metabolized to (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate | ? | |
arachidonate + O2 | the enzyme is involved in production of biologically active lipid mediators, (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate, 13-HODE, and 13-HOTE, in the intestine of iron-deficient rats, the lipids are almoste absent in wild-type rats, overview | Rattus norvegicus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | further metabolized to (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate | ? | |
additional information | intestinal leukocyte-type isozyme Alox15 shows poor or no 15-lipoxygenase activity, EC 1.13.11.33 | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12-lipoxygenase | - |
Rattus norvegicus |
Alox15 | - |
Rattus norvegicus |