Cloned (Comment) | Organism |
---|---|
full-length cDNA for 12/15LO subcloned into vector pACCMVpLpA. Bone marrow-derived macrophages infected at a multiplicity of infection of 50 for 48 h with recombinant adenoviral vector AdLO to overexpress 12/15LO | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P39654 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | macrophages that overexpress 12/15LO have reduced ATP-binding cassette G1 expression, increased transporter phosphorylation, and reduced cholesterol efflux | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Mus musculus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12/15-lipoxygenase | - |
Mus musculus |
12/15LO | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | macrophages that lack 12/15LO have enhanced transporter expression, reduced ATP-binding cassette G1 phosphorylation, and increased cholesterol efflux | Mus musculus |
physiological function | 12/15LO plays a key role in activating the mitogen-activated protein kinase pathway. 12/15LO regulates ATP-binding cassette G1 expression and function through p38- and c-Jun N-terminal kinase 2-dependent mechanisms | Mus musculus |